Pancreatic Cell News Volume 12.45 | Nov 16 2021

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    2021-11-16 | PACN 12.45


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 12.45 – 16 November, 2021
    TOP STORY

    Lipid Droplets Protect Human β-Cells from Lipotoxicity-Induced Stress and Cell Identity Changes

    To obtain insight into the role of lipid droplets (LD) in human islet β-cell function, the levels of a key LD scaffold protein, perilipin 2, were manipulated by lentiviral-mediated knockdown or overexpression in EndoCβH2-Cre cells, a human cell line with adult islet β-like properties.
    [Diabetes]

    Full Article

    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Microtubules Regulate Pancreatic β Cell Heterogeneity via Spatiotemporal Control of Insulin Secretion Hot Spots

    Researchers utilized mouse islets to determine how microtubules affect secretion toward the vascular extracellular matrix at single cell and subcellular levels.
    [eLife]

    Abstract

    Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion

    Researchers reported increased expression of miR-200c in islets from type 2 diabetes as compared with non-diabetic donors and displayed results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c.
    [Diabetes]

    Abstract

    Molecular Mechanisms Responsible for the Sexual Dimorphism in Pancreatic β-Cell Insulin Release: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

    Scientists showed that stepwise increase in extracellular glucose concentration induced electrical activity in β cells of both sexes with similar glucose sensitivity
    [Journal of General Physiology]

    Abstract

    Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells

    Researchers identified the cell surface binding partner of regenerating gene 4 (Reg4) and dissected its role in colorectal cancer (CRC) and pancreatic cancer (PC) growth and stem cell survival. In vitro models of human CRC and PC were used to evaluate the results.
    [Molecular Cancer Research]

    Abstract

    Fluvastatin Sensitizes Pancreatic Cancer Cells toward Radiation Therapy and Suppresses Radiation- and/or TGF-β-Induced Tumor-Associated Fibrosis

    Investigators evaluated the radiosensitizing and anti-radiation induced fibrosis potential of fluvastatin in pancreatic cancer (PC). Short-term viability and clonogenic survival assays were used to evaluate the radiosensitizing potential of fluvastatin in multiple human and murine PC cell lines.
    [Laboratory Investigation]

    Abstract

    Apoptosis-Associated Speck-Like Protein Containing a CARD Regulates the Growth of Pancreatic Ductal Adenocarcinoma

    Scientists clarified the role and mechanisms of action of apoptosis-associated speck-like protein containing a caspase recruitment domain in pancreatic ductal adenocarcinoma using clinical evidence and in vitro data.
    [Scientific Reports]

    Full Article

    The Low-Complexity Domains of the KMT2D Protein Regulate Histone Monomethylation Transcription to Facilitate Pancreatic Cancer Progression

    Researchers identified some core proteins, including WDR5, RBBP5, and ASH2L, which were involved in the histone lysine methyltransferase 2D (KMT2D)-associated catalytic complex in KMT2D low complexity domain-deficient cells to further elucidate the mechanism that decreases monomethylation of H3K4.
    [Cellular & Molecular Biology Letters]

    Full Article

    ACY-241, an HDAC6 Inhibitor, Overcomes Erlotinib Resistance in Human Pancreatic Cancer Cells by Inducing Autophagy

    Researchers evaluated the anticancer effect of ACY-241, a histone deacetylase 6 (HDAC6)-selective inhibitor, on erlotinib-resistant pancreatic cancer cells that overexpressed HDAC6.
    [Archives of Pharmacal Research]

    Abstract

    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Role of circRNA-miRNA-mRNA Interaction Network in Diabetes and Its Associated Complications

    The authors focus on the circRNA-miRNA-mRNA interaction network that influences the gene expression in the progression of diabetes and its associated complications.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    CRISPR Therapeutics and ViaCyte, Inc. to Start Clinical Trial of the First Gene-Edited Cell Replacement Therapy for Treatment of Type 1 Diabetes

    CRISPR Therapeutics, AG. and ViaCyte, Inc., announced that Health Canada has approved the companies’ Clinical Trial Application for VCTX210, an allogeneic, gene-edited, immune-evasive, stem cell-derived therapy for the treatment of type 1 diabetes. Initiation of patient enrollment is expected by year-end.
    [CRISPR Therapeutics, AG.]

    Press Release

    FEATURED EVENT

    Cancer Genomics

    November 22 – 24, 2021
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    JOB OPPORTUNITIES

    Clinical Operations Manager – Clinical Research

    NUI Galway – Galway, Ireland

    Research Associate – Obesity and Metabolic Disorders

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Type II Diabetes

    Harvard Medical School – Boston, Massachusettes, United States

    Postdoctoral Position – Pancreatic Adenocarcinoma

    University of California Los Angeles – Los Angeles, California, United States

    Postdoctoral Associate – Neurobiology of Obesity and Diabetes

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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