 | | Vol. 12.47 – 30 November, 2021 |
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| Investigators described a strategy that utilizes pretargeting and glycochemistry to bioengineer β cells in situ to induce β-cell-specific tolerance.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that Tentonin 3/TMEM150C, a mechanosensitive channel, contributed to glucose-stimulated insulin secretion by mediating cation influx.
[Cell Reports] |
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| The authors found that the RIIB subunit of protein kinase A was expressed specifically by β cells of mouse and human islets.
[FEBS Journal] |
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| Researchers showed that endoplasmic reticulum (ER) to Golgi transfer of vesicular cargo proteins required WFS1, an ER-associated membrane protein whose loss of function led to Wolfram syndrome.
[Nature Communications] |
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| It was observed that poly(2-oxazoline)-based polymeric micelles could be elongated over time from a spherical structure to worm-like structure, with elongation influenced by several conditions, including the amount and type of drug loaded into the micelles.
[Small] |
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| Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.
[Cell Reports] |
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| The authors identified that glutamine limitation in pancreatic ductal adenocarcinoma cells suppressed de novo hexosamine synthesis but resulted in increased free GlcNAc abundance.
[eLife] |
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| Scientists identified that lysyl oxidase-like 2 was a hypoxia-responsive gene and was essential for the Warburg effect in PDAC.
[Cell Death & Disease] |
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| Researchers analyzed the alteration of collagen and gene expression profiles in pancreatic cancer tissues after neoadjuvant therapy. They examined the biological role of Ephrin-A5 using primary cultured cancer-associated fibroblasts.
[British Journal of Cancer] |
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| Investigators showed that Akr1c19 expression was dramatically decreased in db/db islets.
[PLoS One] |
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| MLKL inhibitor NSA attenuated the killing effect of IMB5036 on pancreatic cancer cells. IMB5036 stimulated translocation of MLKL and p-MLKL from cytoplasm to cell membrane.
[Basic & Clinical Pharmacology & Toxicology] |
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| Cell-free DNA biomarkers indicate accelerated progression and decreased survival in PDAC.
[Critical Reviews in Oncology Hematology] |
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| Regeneration proceedings for pancreatic β cells are promising and could improve β-cell proliferation capacity and contribute to the conservation of mature β-cell phenotypic characteristics.
[Endocrine] |
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| The Azrieli Faculty of Medicine at Bar-Ilan University and The Russell Berrie Foundation announced a new $75 million, comprehensive 10-year program to help transform diabetes care, with the simultaneous goal of spurring innovations in diabetes treatment and prevention that can be applied around the world.
[The Jerusalem Post] |
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| The California Institute for Regenerative Medicine governing board approved a $4.1 million grant to enable University of California San Diego School of Medicine researchers to advance a new chimeric antigen receptor (CAR) T cell therapy from the laboratory into the clinic.
[Technology Networks] |
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| January 9 – 12, 2022
Portland, Oregon, United States |
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| | Helmholtz Zentrum München – German Research Center for Environmental Health – Neuherberg, Germany |
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| | Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | NUI Galway – Galway, Ireland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Harvard Medical School – Boston, Massachusettes, United States |
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