 | | Vol. 12.49 – 14 December, 2021 |
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| Researchers showed that hormonal FABP4 formed a functional hormone complex with adenosine kinase and nucleoside diphosphate kinase to regulate extracellular ATP and ADP levels.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified cyanidin-3-rutinoside’s (C3R) mechanisms of action in pancreatic β-cells. Rat INS-1 cells were used to elucidate the effects of C3R on insulin secretion, intracellular Ca2+ signaling, and gene expression.
[Biomedicine & Pharmacotherapy] |
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| Researchers reported that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors, thereby conferring to rat islets their competence to exhibit first phase glucose-stimulated insulin secretion.
[Journal of Biological Chemistry] |
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| Investigators provided evidence that elevated levels of human SMO showed a strong correlation with elevated levels of insulin-like growth factor 1 receptor and reduced survival in diffuse large B cell lymphoma.
[Laboratory Investigation] |
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| HK-2 cell viability and apoptosis were detected by Cell Counting Kit-8 assay and flow cytometry analysis, respectively. β-amyrin was found to ameliorate kidney injury in diabetic nephropathy mice and suppressed inflammatory response as well as apoptosis of high glucose-stimulated HK-2 cells.
[Environmental Toxicology] |
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| Scientists identified and characterized resistance mechanisms to a FIRINOX chemotherapy regimen because it was the most aggressive regimen currently used clinically for patients with PDAC.
[Science Translational Medicine] |
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| Using genetically defined models, researchers showed that histone deacetylase (HDAC2) was a cellular fitness factor that controls cell cycle in vitro and metastasis in vivo, particularly in undifferentiated, mesenchymal PDAC.
[Cancer Research] |
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| Synaptotagmin-8 (SYT8) is a membrane protein that regulates hormone secretion and neurotransmission, and its expression is positively regulated by the promoter of the insulin gene in pancreatic islet cells. The authors identified a previously unknown role of SYT8 in altering tumor characteristics in pancreatic cancer.
[Cell Death Discovery] |
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| Scientists investigated the function of miR-199 on gemcitabine-resistance in pancreatic cancer, as well as the underlying mechanism.
[ACS Omega] |
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| Weight loss-induced decrease of intra-pancreatic fat is tightly associated with remission of type 2 diabetes mellitus and its re-deposition with recurrence of the disease.
[Nature Reviews Gastroenterology & Hepatology] |
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| Investigators describe mechanisms involved in insulin secretion as well as metabolic and mitogenic actions on its target tissues.
[Peptides] |
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| Trevena, Inc. announced it is advancing TRV045 into clinical development, following receipt of a notification from the US FDA that the study may proceed.
[Trevena, Inc.] |
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| January 21 -23, 2022
Austin, Texas, United States |
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| University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Harvard Medical School – Boston, Massachusettes, United States |
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