 | | Vol. 13.01 – 4 January, 2022 |
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| Cell lines were isolated from Ptf1a-Cre;LSL-KrasG12D;Rnf43flox/flox and Ptf1a-Cre; LSL-KrasG12D tumors and interrogated by cytokine array analyses, ATAC-seq and in vitro drug assays.
[Gastroenterology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified Ser44 as an fibroblast growth factor 1 (FGF1)-induced regulatory phosphorylation site in phosphodiesterase 4D that was modulated by the feed-fast cycle
[Cell Metabolism] |
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| In a cell-based in vitro bioassay, scientists used mouse β-TC-6 cancer cells and found 48-hour exposure to perfluorooctane sulfonate (PFOS) decreased the cell viability at 50 μmol/L.
[Journal of Environmental Sciences] |
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| Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| FGD3, which is involved in regulating the actin cytoskeleton and cell shape, has been reported to inhibit cancer cell migration and predict a favorable prognosis in multiple types of cancer. Researchers conducted a systematic investigation of the cancer-related role of FGD3 in pancreatic cancer.
[Oncogene] |
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| Researchers explored the use of soluble AXL as a biomarker for pancreatic ductal adenocarcinoma. AXL was analyzed by immunohistochemistry in human pancreatic tissue samples.
[Ebiomedicine] |
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| Scientists investigated the expression of hsa_circ_0074298 and the molecular mechanism that promoted tumor growth and enhanced the chemoresistance of pancreatic cancer.
[Journal of Cancer] |
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| Researchers developed a new PAK4 inhibitor, PAKib, and tested its effect on pancreatic cancer (PC) cell growth in vitro and in a syngeneic mouse model of PC.
[Translational Oncology] |
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| Investigators analyzed the correlation between Sonic Hedgehog or Gli1 and osteopontin expression in human pancreatic ductal adenocarcinoma. They also evaluated the proliferation, apoptosis, migration, and invasion of Gli1-knockdown BxPC-3 cells.
[Cancer Biotherapy and Radiopharmaceuticals] |
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| C-Myc overexpression is a common finding in pancreatic cancer and predicts the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby regulating their transcription.
[Cancer Biology & Therapy] |
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| Beta Bionics, Inc. announced the completion of the randomized controled trial for the Insulin-Only Bionic Pancreas Pivotal Trial and enrollment into the screening protocol of the Bihormonal Bionic Pancreas Pivotal Trial at Massachusetts General Hospital.
[Beta Bionics, Inc.] |
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| February 5 – 9, 2022
Maui, Hawaii, United States |
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| University of Cincinnati – Cincinnati, Ohio, United States |
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| Tandem Diabetes Care – Toronto, Ontario, Canada |
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| University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| Harvard Joslin Diabetes Center – Boston, Massachusetts, United States |
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