 | | Vol. 13.01 – 11 January, 2022 |
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| Researchers demonstrated that PDAC tumors established an organized communication network between subpopulations of cancer cells using extracellular vesicles called the EVNet.
[Gut] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that increased expression of the transcription factor Grainyhead 1 promoted lifespan and pathogen resistance in Caenorhabditis elegans.
[Nature Communications] |
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| Researchers showed that insulin secretion sites also contained non-neuronal proteins LL5β and KANK1, which in migrating cells organized exocytotic machinery in the vicinity of integrin-based adhesions.
[Journal of Cell Science] |
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| The authors hypothesized that LIM domain-binding protein 1 (LDB1) and/or islet-1 levels, like other transcriptional regulators, were sensitive to β-cell nutrient and cytokine stresses, likely contributing to β-cell (dys)function under various stimuli.
[Islets] |
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| Scientists monitored changes of the intracellular Ca2+ concentration as an immediate read-out for insulin secretion in live cell experiments.
[Physiological Reports] |
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| Researchers characterized the function of tumor-derived progranulin in promoting immune evasion in primary PDAC.
[Nature Communications] |
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| By analysing publicly available transcriptomic data of patient samples and cell lines, scientists identified two specific glycan profiles in PDAC that correlated with progression, clinical outcome and epithelial to mesenchymal transition status.
[Communications Biology] |
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| Poly(ADP-ribose) polymerase 1 (PARP1) and checkpoint kinase 1 (Chk1) inhibitors have been shown to be synergistic in different cancer models in relatively short time treatment modes. The synergistic cytotoxicity of their combinations in eight tumor cell lines was confirmed in a seven day exposure mode.
[Cancer Biology & Therapy] |
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| Researchers evaluated the in vitro internalization of the 19F-labelled p-boronophenylalanine (19F-BPA) in the human cancer pancreatic cell line for the potential application of boron neutron capture therapy and proton boron fusion therapy in pancreatic cancer.
[Physica Medica-European Journal of Medical Physics] |
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| Scientists discuss recent advances in inter-organ communication from the metabolic, immune, and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function, as well as their role in the adaptive responses of islet to nutrition-induced stress.
[Febs Letters] |
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| Biomea Fusion, Inc. announced that in 2022 it plans to initiate clinical studies to dose its irreversible covalent menin inhibitor, BMF-219, in up to seven different cancer indications as well as in diabetes.
[Biomea Fusion, Inc.] |
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| February 10 – 12, 2022
Lorne, Victoria, Australia |
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| Ume̴ University РUme̴, Sweden |
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| University of Cincinnati – Cincinnati, Ohio, United States |
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| Tandem Diabetes Care – Toronto, Ontario, Canada |
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| University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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