 | | Vol. 13.02 – 18 January, 2022 |
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| 6-aminopicolamine (6AP) acted as a water-soluble prodrug that was converted into intracellular bioactive metabolites that inhibited phosphogluconate dehydrogenase in vitro, and 6AP monotherapy demonstrated anti-metastatic efficacy with minimal toxicity in vivo.
[Oncogene] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists presented a light-sheet fluorescence microscopy approach to image the pancreas in 3D and map tissue interactions at key time points in the mouse embryo.
[Development] |
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| Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) 2 locus and found that NOD B10-Idd2 congenic mice were highly resistant to diabetes.
[Journal of Immunology] |
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| Rescue assays of cells overexpressing metastasis-related in colon cancer 1 (MACC1)-AS1 and of cells silencing MACC1 were performed and cellular properties and proteins were assessed.
[Clinical and Translational Medicine] |
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| Researchers demonstrated that perfluorooctanoic acid induced oxidative stress and focal ductal hyperplasia in the mouse pancreas.
[Carcinogenesis] |
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| Molecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma patients. The 173 samples were divided into three categories and a 3-gene signature model was constructed.
[Cancer Cell International] |
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| Scientists probed molecular regulatory mechanism of KLF4 in malignant progression of pancreatic cancer.
[Cell Death Discovery] |
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| The authors investigated the expression of two programmed cell death (PD)-1 ligands, PD-L1 and PD-L2, in pancreatic ductal adenocarcinoma, analyzed their role in survival, and explored their correlation with clinicopathological features, immune infiltration, and DNA damage response molecules.
[Journal of Pathology Clinical Research] |
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| Analysis of matrix remodeling-associated protein 8 (MXRA8) expression in human pancreatic ductal adenocarcinoma samples showed that MXRA8 was differentially co-expressed with other cancer-associated fibroblasts markers.
[Pathology International] |
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| In pancreatic cancer, exosomes are enriched with multiple signaling molecules that mediate intercellular communication with control of immune suppression, mutual promotion between pancreas stellate cells and pancreatic cancer cells, and reprogramming of normal cells.
[Cell Communication and Signaling] |
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| Zai Lab Limited announced treatment of the first patient in Greater China in the PANOVA-3 trial, a Phase III pivotal trial of Tumor Treating Fields in patients with pancreatic cancer.
[Zai Lab Limited] |
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| German Research Center – Oberschleißheim, Germany |
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| Ume̴ University РUme̴, Sweden |
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| University of Cincinnati – Cincinnati, Ohio, United States |
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| Tandem Diabetes Care – Toronto, Ontario, Canada |
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| University of Oklahoma – Oklahoma City, Oklahoma, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
