Pancreatic Cell News Volume 13.03 | Jan 25 2022

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    2022-01-25 | PACN 13.03


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.03 – 25 January, 2022
    TOP STORY

    A MicroRNA Checkpoint for Ca2+ Signaling and Overload in Acute Pancreatitis

    Scientists showed that microRNA-26a inhibited pancreatic acinar cell store-operated Ca2+ entry channel expression, Ca2+ overload, and acute pancreatitis.
    [Molecular Therapy]

    AbstractGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes

    Scientists demonstrated that PTPN2 inactivation in β-cells exacerbates type I and type II interferon signaling networks and the potential progression towards autoimmunity.
    [Diabetes]

    Abstract

    Sodium Butyrate Potentiates Insulin Secretion from Rat Islets at the Expense of Compromised Expression of β Cell Identity Genes

    Overlapping analysis of H3K27Ac ChIP-seq and RNA-seq showed that the inhibitory effect of sodium butyrate on the expression of multiple β cell identity genes was independent of H3K27Ac.
    [Cell Death & Disease]

    Full Article

    SENP2 Regulates Mitochondrial Function and Insulin Secretion in Pancreatic β Cells

    Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.
    [Experimental and Molecular Medicine]

    Full Article

    Antioxidation of a Proteoglycan from Ganoderma lucidum Protects Pancreatic β Cells against Oxidative Stress-Induced Apoptosis In Vitro and In Vivo

    Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.
    [International Journal of Biological Macromolecules]

    Abstract

    ER Stress-Induced Cell Death Proceeds Independently of the TRAIL-R2 Signaling Axis in Pancreatic β Cells

    Scientists investigated if TRAIL-R2 dependent signaling towards apoptosis could be induced in pancreatic β cells, whose loss by prolonged ER stress was associated with the onset of diabetes.
    [Cell Death Discovery]

    Full Article

    The Inhibition of Panc1 Cancer Cells Invasion by hAMSCs Secretome through Suppression of Tyrosine Phosphorylation of SGK223 (at Y411 Site), C-src (at Y416, Y530 Sites), AKT Activity, and JAK1/Stat3 Signaling

    Researchers employed a co-culture system to clarify the effects of human amniotic mesenchymal stromal cells secretome through tyrosine phosphorylation of c-Src, SGK223, AKT activity, and JAK1/Stat3 signaling in Panc1 pancreatic cancer cells.
    [Medical Oncology]

    Abstract

    Abnormal Exocrine–Endocrine Cell Cross-Talk Promotes β Cell Dysfunction and Loss in MODY8

    Investigators reported the transfer of carboxyl ester lipase proteins from acinar cells to β cells as a form of cross-talk between exocrine and endocrine cells.
    [Nature Metabolism]

    Abstract

    Interactions with Stromal Cells Promote a More Oxidized Cancer Cell Redox State in Pancreatic Tumors

    Scientists used optical imaging to assess the redox state of pancreatic cancer cells and PSCs and find that direct interactions between PSCs and cancer cells promote a more oxidized state in cancer cells.
    [Science Advances]

    Full Article

    XP-524 Is a Dual-BET/EP300 Inhibitor That Represses Oncogenic KRAS and Potentiates Immune Checkpoint Inhibition in Pancreatic Cancer

    Researchers demonstrated that the multispecificity BET/EP300 inhibitor XP-524 had pronounced single-agent efficacy in vitro, in vivo, and ex vivo human PDAC slice cultures, functioning in part by attenuating oncogenic KRAS signaling.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

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    REVIEWS

    Urocortin3: Local Inducer of Somatostatin Release and Bellwether of Beta Cell Maturity

    Scientists review the mechanistic underpinnings of urocortin 3 signaling, its net effect on islet cell hormone output, as well as its value as a marker for beta cell maturation and functional status.
    [Peptides]

    Abstract

    INDUSTRY AND POLICY NEWS

    Marker Therapeutics Receives FDA Orphan Drug Designation for Its Multi-Antigen Targeted T Cell Therapy for Pancreatic Cancer

    Marker Therapeutics, Inc. announced that the US FDA Office of Orphan Products Development has granted Orphan Drug designation to MT-601, a multi-tumor-associated antigen-specific T cell product optimized for the treatment of patients with pancreatic cancer.
    [Marker Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Cell Symposium: Viruses in Health and Disease

    March 20 – 22, 2022
    Sitges, Spain

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Diabetes Research

    Uppsala University – Uppsala, Sweden

    Postdoctoral Fellow – Molecular Medicine

    Ume̴ University РUme̴, Sweden

    Assistant Professor – Cancer Biology

    University of Cincinnati – Cincinnati, Ohio, United States

    Postdoctoral Research Fellow – Diabetes, and Metabolism

    University of Illinois at Chicago – Chicago, Illinois, United States

    Chair – Physiology

    University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States

    > See All Jobs

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