Pancreatic Cell News Volume 13.04 | Feb 1 2022

May 12, 2022

2022-02-01 | PACN 13.04

Pancreatic Cell News by STEMCELL Technologies

Vol. 13.04 – 1 February, 2022

TOP STORY

Autonomous Sensing of the Insulin Peptide by an Olfactory G Protein-Coupled Receptor Modulates Glucose Metabolism

By screening the expression and functional characterization of olfactory receptors in pancreatic islets, scientists identified Olfr109 as the receptor that detected insulin peptides.
[Cell Metabolism]

Full Article Graphical Abstract

New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.

PUBLICATIONSRanked by the impact factor of the journal

DIABETES & PANCREATITIS

Heterogenous Impairment of α Cell Function in Type 2 Diabetes Is Linked to Cell Maturation State

Investigators examined α cells from human donors and mice using electrophysiological, transcriptomic, and computational approaches.
[Cell Metabolism]

Full Article Graphical Abstract

Disruption of Pancreatic Stellate Cell Myofibroblast Phenotype Promotes Pancreatic Tumor Invasion

Researchers showed that the Rho effector protein kinase N2 (PKN2) was critical for pancreatic stellate cell (PSC) myofibroblast differentiation. Loss of PKN2 was associated with reduced PSC proliferation, contractility, and alpha-smooth muscle actin stress fibers.
[Cell Reports]

Full Article Graphical Abstract

LncRNA MEG3 Regulates Autophagy and Pyroptosis via FOXO1 in Pancreatic β-Cells

Scientists investigated whether the lncRNA MEG3 could regulate autophagy and pyroptosis through FOXO1 in pancreatic β-cells.
[Cellular Signalling]

Full Article Graphical Abstract

Synthetic Small Molecules to Induce Insulin Secretion and Pancreatic Beta Cell Specific Gene Expression

A family of new small molecules that are structurally similar to glinides was synthesized through three different synthetic methods and categorized into three categories.
[Cells Tissues Organs]

Abstract

PANCREATIC CANCER

Enhanced ROS-Boosted Phototherapy against Pancreatic Cancer via Nrf2-Mediated Stress-Defense Pathway Suppression and Ferroptosis Induction

To overcome the tumor hypoxia and thermal resistance existing in phototherapy, the authors constructed a self-synergistic nanoplatform for tumors by incorporating brusatol, a nuclear factor erythroid 2-related factor (Nrf2) inhibitor, into the silica nanonetwork.
[ACS Applied Materials & interfaces]

Abstract Graphical Abstract

De Novo Expression of Gastrokines in Pancreatic Precursor Lesions Impede the Development of Pancreatic Cancer

Scientists performed the molecular and histological assessment of patient-derived PanINs, tumor tissues and pancreas from mouse models with PDAC, where they noted marked upregulation of gastrokine proteins.
[Oncogene]

Full Article

A Low Amino Acid Environment Promotes Cell Macropinocytosis through the YY1-FGD6 Axis in Ras-Mutant Pancreatic Ductal Adenocarcinoma

Researchers identified a key regulator of macropinocytosis for the survival of tumor cells in a low amino acid environment in PDAC.
[Oncogene]

Full Article

Novel Necroptosis-Related Gene Signature for Predicting the Prognosis of Pancreatic Adenocarcinoma

Scientists investigated the necroptosis-related genes’ prediction potential in pancreatic adenocarcinoma samples from the TCGA and GEO datasets.
[Aging]

Full Article

Visceral Adipose Tissue Remodeling in Pancreatic Ductal Adenocarcinoma Cachexia: The Role of Activin a Signaling

The authors proposed that activin A signaling could be relevant to the acceleration of visceral adipose tissue wasting in PDAC-associated cachexia.
[Scientific Reports]

Full Article

The Inhibitory Effect of LINC00261 Upregulation on the Pancreatic Cancer EMT Process Is Mediated by KLF13 via the mTOR Signaling Pathway

The location of LINC00261 in pancreatic cancer cells was identified by RNA fluorescence in situ hybridization.
[Clinical and Translational Oncology]

Abstract

Selective Multi-Kinase Inhibition Sensitizes Mesenchymal Pancreatic Cancer to Immune Checkpoint Blockade by Remodeling the Tumor Microenvironment

Scientists performed a systematic high-throughput combination drug screen and identified a synergistic interaction between the MEK inhibitor trametinib and the multi-kinase inhibitor nintedanib, which targeted KRAS-directed oncogenic signaling in mesenchymal PDAC.
[Nature Cancer]

Abstract

REVIEWS

The Next Wave of Cellular Immunotherapies in Pancreatic Cancer

The authors provide an overview of current and on-going chimeric antigen receptor (CAR) T cell clinical studies in pancreatic cancer and the major challenges and strategies to improve CAR T cell efficacy.
[Molecular Therapy-Oncolytics]

Abstract Full Article Graphical Abstract

INDUSTRY AND POLICY NEWS

Panbela Initiates a Randomized, Double-Blind, Placebo-Controlled Study (ASPIRE) of Nab-Paclitaxel and Gemcitabine with or without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

Panbela Therapeutics, Inc. announced the initiation of the company’s global Phase II clinical trial of SBP-101 in combination with Gemcitabine and Nab-Paclitaxel in patients with metastatic PDAC, which is referred to as the ASPIRE trial.
[Panbela Therapeutics, Inc.]

Full Article

Karmanos Cancer Institute Awarded $352,000 Grant from U CAN-CER VIVE Foundation

The Barbara Ann Karmanos Cancer Institute recently received a $352,437 grant from the U CAN-CER VIVE Foundation to help fund a pancreatic cancer research study.
[Karmanos Cancer Institute]

Full Article

FEATURED EVENT

Autonomous Sensing of the Insulin Peptide by an Olfactory G Protein-Coupled Receptor Modulates Glucose Metabolism

Heterogenous Impairment of α Cell Function in Type 2 Diabetes Is Linked to Cell Maturation State

Disruption of Pancreatic Stellate Cell Myofibroblast Phenotype Promotes Pancreatic Tumor Invasion

LncRNA MEG3 Regulates Autophagy and Pyroptosis via FOXO1 in Pancreatic β-Cells

Synthetic Small Molecules to Induce Insulin Secretion and Pancreatic Beta Cell Specific Gene Expression

Enhanced ROS-Boosted Phototherapy against Pancreatic Cancer via Nrf2-Mediated Stress-Defense Pathway Suppression and Ferroptosis Induction

De Novo Expression of Gastrokines in Pancreatic Precursor Lesions Impede the Development of Pancreatic Cancer

A Low Amino Acid Environment Promotes Cell Macropinocytosis through the YY1-FGD6 Axis in Ras-Mutant Pancreatic Ductal Adenocarcinoma

Novel Necroptosis-Related Gene Signature for Predicting the Prognosis of Pancreatic Adenocarcinoma

Visceral Adipose Tissue Remodeling in Pancreatic Ductal Adenocarcinoma Cachexia: The Role of Activin a Signaling

The Inhibitory Effect of LINC00261 Upregulation on the Pancreatic Cancer EMT Process Is Mediated by KLF13 via the mTOR Signaling Pathway

Selective Multi-Kinase Inhibition Sensitizes Mesenchymal Pancreatic Cancer to Immune Checkpoint Blockade by Remodeling the Tumor Microenvironment

The Next Wave of Cellular Immunotherapies in Pancreatic Cancer

Panbela Initiates a Randomized, Double-Blind, Placebo-Controlled Study (ASPIRE) of Nab-Paclitaxel and Gemcitabine with or without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

Karmanos Cancer Institute Awarded $352,000 Grant from U CAN-CER VIVE Foundation

EMBO: Microbial Infections and Human Cancer

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Postdoctoral Fellow – Cancer Immune Biomarkers

Postdoctoral Position – Proteome Dynamics

Research Assistant – Kidney Cancer Organoids

PhD Student – Diabetes Research

Research Associate – Cancer Biology

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