Pancreatic Cell News Volume 13.05 | Feb 8 2022

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    2022-02-08 | PACN 13.05


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.05 – 8 February, 2022
    TOP STORY

    Human Pluripotent Stem-Cell-Derived Islets Ameliorate Diabetes in Non-Human Primates

    Researchers generated islets from human chemically induced pluripotent stem cells (hCiPSC-islets) and showed that a one-dose intraportal infusion of hCiPSC-islets into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.
    [Nature Medicine]

    Full Article

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    The IGFBP3/TMEM219 Pathway Regulates Beta Cell Homeostasis

    Scientists showed that the death receptor TMEM219 was expressed on pancreatic beta cells and that signaling through its ligand insulin-like growth factor binding protein 3 (IGFBP3) led to beta cell loss and dysfunction.
    [Nature Communications]

    Full Article

    Beta-Cell Specific Insr Deletion Promotes Insulin Hypersecretion and Improves Glucose Tolerance Prior to Global Insulin Resistance

    RNA-seq of purified recombined β-cells revealed transcriptomic consequences of Insr loss, which differed between female and male mice.
    [Nature Communications]

    Full Article

    YY1 Regulates Glucose Homeostasis through Controlling Insulin Transcription in Pancreatic Beta Cells

    Following beta cell ablation of Yy1, scientists observed rapid onset of hyperglycemia, impaired glucose tolerance and reduced beta cell mass in both neonates and adult mice.
    [Diabetes]

    Abstract

    Proinflammatory Cytokines Induce Rapid, NO-Independent Apoptosis, Expression of Chemotactic Mediators and Interleukin-32 Secretion in Human Pluripotent Stem Cell-Derived Beta Cells

    Investigators examined the effects of proinflammatory cytokines on cells of different developmental stages during the generation of stem cell-derived beta cells from human pluripotent stem cells.
    [Diabetologia]

    Full ArticleGraphical Abstract

    The Anthelmintic Drug Niclosamide Induces GSK-β-Mediated β-Catenin Degradation to Potentiate Gemcitabine Activity, Reduce Immune Evasion Ability and Suppress Pancreatic Cancer Progression

    Niclosamide inhibited proliferation of pancreatic cancer cells, induced apoptosis via the mitochondrial-mediated pathway, and suppressed cell migration and invasion by antagonizing epithelial-to-mesenchymal transition.
    [Cell Death & Disease]

    Full Article

    Fungal Mycobiome Drives IL-33 Secretion and Type 2 Immunity in Pancreatic Cancer

    The authors showed that oncogenic KrasG12D increased IL-33 expression in PDAC cells, which recruited and activated TH2 and innate lymphoid cells 2 cells.
    [Cancer Cell]

    AbstractGraphical AbstractPress Release

    Synthetic Adiponectin-Receptor Agonist, AdipoRon, Induces Glycolytic Dependence in Pancreatic Cancer Cells

    Treatment of PDAC cells with AdipoRon led to mitochondrial uncoupling and loss of ATP production. Concomitantly, AdipoRon-treated cells increased glucose uptake and utilization.
    [Cell Death & Disease]

    Full Article

    IGF-1R/YAP Signaling Pathway Is Involved in Collagen V-induced Insulin Biosynthesis and Secretion in Rat Islet INS-1 Cells

    The protein level of insulin-like growth factor 1 receptor (IGF-1 R), detected as the upstream molecule of Yes-associated protein (YAP), was reduced in the INS-1 cells cultured on the dishes coated with collagen V.
    [Connective Tissue Research]

    Abstract

    Involvement of Activator Protein-1 Family Members in β-Catenin and p300 Association on the Genome of PANC-1 Cells

    Researchers investigated regulatory mechanisms underlying β-catenin coactivator usage in human pancreatic carcinoma PANC-1 cells through combinatorial analysis of chromatin immunoprecipitation-sequencing and RNA-sequencing.
    [Heliyon]

    Full Article

    Watch a webinar on using patient-derived iPS cells to model diabetes.
    REVIEWS

    Application of Magnetic Resonance Imaging in Neoadjuvant Treatment of Pancreatic Ductal Adenocarcinoma

    Scientists investigate and summarize the advantages, limitations, and future development of magnetic resonance imaging in the evaluation of neoadjuvant treatment of PDAC.
    [Journal of Magnetic Resonance Imaging]

    Abstract

    INDUSTRY AND POLICY NEWS

    CRISPR Therapeutics and ViaCyte, Inc. Announce First Patient Dosed in Phase I Clinical Trial of Novel Gene-Edited Cell Replacement Therapy for Treatment of Type 1 Diabetes (T1D)

    CRISPR Therapeutics and ViaCyte, Inc. announced the first patient has been dosed in the Phase I clinical trial of VCTX210 for the treatment of T1D.
    [CRISPR Therapeutics]

    Press Release

    FEATURED EVENT

    ISCT ANZ – BAA Joint Scientific Meeting

    February 24 – February 25, 2022
    Virtual

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    JOB OPPORTUNITIES

    Post-Doctoral Researcher – Anti-Diabetic Drug

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Cancer Immune Biomarkers

    Albert Einstein College of Medicine – Bronx, New York, United States

    Postdoctoral Position – Proteome Dynamics

    University of Texas Medical Branch – Galveston, Texas, United States

    Research Assistant – Kidney Cancer Organoids

    Knight Cancer Institute – Portland, Oregon, United States

    PhD Student – Diabetes Research

    Uppsala University – Uppsala, Sweden

    > See All Jobs

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