 | | Vol. 13.07 – 22 February, 2022 |
| |
|
|
| Scientists generated 15 g of a tricyclic intermediate in 8 steps from (R)-limonene and 720 mg of a penultimate bioactive intermediate in a protecting-group-free manner.
[Angewandte Chemie-International Edition] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| The authors used an in vitro MIN6 cell model of environment-relevant cadmium exposure to elucidate the crucial role of mtROS-mediated mitochondrial dysfunction and inflammatory response in the suppression of pancreatic β-cell insulin secretion.
[Journal of Trace Elements in Medicine and Biology] |
|
|
|
| Scientists found that palmitic acid stimulation led to M1 polarization of macrophage, which secreted cathepsin S via exosomes to pancreatic acinar cells and led to activation of the caspase1-mediated classical pyrolysis pathway.
[BMC Gastroenterology] |
|
|
|
| Researchers described the radiolabeling, in vitro and in vivo evaluation of a bi-terminally PEGylated A20FMDV2 conjugated with DOTA or PCTA for 64Cu radiolabeling.
[Oncotarget] |
| |
|
|
| Investigators investigated the effect of circCUL2 on inflammatory cancer-associated fibroblast activation, heterogeneity and protumor activity by ELISA, flow cytometry, colony formation and transwell assays in vitro and by xenograft models in vivo.
[Journal of Experimental & Clinical Cancer Research] |
|
|
|
| Scientists performed thorough histopathological analyses and single-cell transcriptomics for both genotypes, Ptf1aCreER;KrasLSL-G12D and sexes.
[Cancer & Metabolism] |
|
|
|
| Researchers described a novel computational method for characterizing toxicity, associated biological perturbations and disease outcome, called the Chemo-Phenotypic Based Toxicity Measurement. The method was validated in the in vitro, in vivo and organoid models.
[Ecotoxicology and Environmental Safety] |
|
|
|
| Scientists found that C-C motif chemokine ligand 2 (CCL2) recruited monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.
[International Immunopharmacology] |
|
|
|
| Expression of circ_0072088, microRNA (miR)-545-3p and solute carrier family 7 member 11 (SLC7A11) was detected by real-time quantitative PCR and western blotting.
[Autoimmunity] |
|  |
|
|
|
| Pancreatic ductal metaplasia (PDM) development might involve all cell lineages of the pancreas, and acinar cells with the highest plasticity are the major source of PDM.
[Journal of Pathology] |
|
|
|
|
| Kiniksa Pharmaceuticals, Ltd. and Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., announced a strategic collaboration to develop and commercialize Kiniksa’s ARCALYST® and mavrilimumab in the Asia Pacific Region.
[Kiniksa Pharmaceuticals, Ltd.] |
|
|
|
|
| 29 – 31 March, 2022
Boston, Massachusetts, United States |
|
|
|
|
|
| OU Health Sciences Center – Oklahoma City, Oklahoma, United States |
|
|
|
| Karolinska Institute – Stockholm, Sweden |
|
|
|
| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
|
|
|
| | Albert Einstein College of Medicine – Bronx, New York, United States |
|
|
|
| | University of Texas Medical Branch – Galveston, Texas, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
