 | | Vol. 13.09 – 8 March, 2022 |
| |
|
|
| Scientists investigated characteristics of newborn beta cells extracted by a time-resolved reporter system. Single-cell RNA sequencing (scRNA-seq) was performed on mouse beta-cell sorted by fluorescent reporters to uncover transcriptomic profiles of newborn beta cells.
[Diabetologia] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Scientists utilized sorting of physically interacting cells with single-cell RNA-sequencing to systematically map cellular interactions in the endocrine pancreas after pancreatectomy.
[Molecular Metabolism] |
|
|
|
| The authors described the generation of an array of monoclonal antibodies against cell surface markers that selectively label stem cell-derived islet cells.
[Stem Cell Reports] |
|
|
|
| Scientists provided a single-cell atlas of pancreatic islets of 24 type 1 diabetes, autoantibody-positive and nondiabetic organ donors across multiple quantitative modalities including ~80,000 cells using single-cell transcriptomics, ~7,000,000 cells using cytometry by time of flight and ~1,000,000 cells using in situ imaging mass cytometry.
[Nature Metabolism] |
| |
|
|
| The authors investigated the potential of domatinostat, a new class I histone deacetylase inhibitor, currently in clinical development, to sensitize PDAC to first line standard gemcitabine/taxol doublet chemotherapy treatment.
[Journal of Experimental & Clinical Cancer Research] |
|
|
|
| Scientists characterized a novel pseudogene-miRNA-mRNA network associated with PDAC progression using bioinformatics analysis. After screening by dreamBase and GEPIA, 12 up-regulated and 7 down-regulated differentially expressed pseudogenes were identified.
[Aging] |
|
|
|
| Investigators explored the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of receptor for advanced glycation end products-initiated signaling in PDAC.
[Phytotherapy Research] |
|
|
|
| Researchers utilized high resolution flow cytometry to detect EVs in the plasma of patients with pancreatic ductal adenocarcinoma (PDAC) and in the supernatants of PDAC and healthy control pancreatic organoid cultures.
[Scientific Reports] |
|
|
|
| Scientists showed that alanine serine cysteine‑preferring transporter 2 (ASCT2) expression was significantly higher in pancreatic cancer than in normal pancreatic duct cells and pancreas.
[Bioscience Reports] |
|
|
|
|
| Nanoparticle drug delivery systems have increased the efficacy of chemotherapeutics by improving the targeting ability of drugs to the tumor site, while also decreasing the risk of local and systemic toxicity.
[Drug Discovery Today] |
|
|
|
| Glucagon is often administered to counteract severe hypoglycaemia, and commonly used diabetes medications such as GLP-1 analogues, sulfonylureas and SGLT2-inhibitors also affect alpha cells.
[Current Opinion in Pharmacology] |
|
|
|
|
| JDRF, the leading global type 1 diabetes research and advocacy organization, announces a new collaboration with leading diabetes, advocacy, and healthcare partners to support a newly established insulin-centered project from Civica Inc.
[JDRF, Inc. (BioSpace, Inc.)] |
|
|
|
|
|
|
|
| Centre for Genomic Regulation – Barcelona, Spain |
|
|
|
| | NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| OU Health Sciences Center – Oklahoma City, Oklahoma, United States |
|
|
|
| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
