 | | Vol. 13.10 – 15 March, 2022 |
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| Investigators generated functionally mature stem-cell-derived islets using an optimized protocol and benchmarked them comprehensively against primary adult islets.
[Nature Biotechnology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers achieved high recovery, viability, function and scalability in mouse, porcine, human, and human stem cell-derived beta cell islets by comprehensive optimization of cryoprotectant agent composition, and methods for vitrification and rewarming.
[Nature Medicine] |
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| Scientists studied the role of lysosomal Ca2+ in transcription Factor EB (TFEB) activation by mitochondrial or metabolic stress and that of TFEB-mediated mitophagy in pancreatic β-cell function.
[Nature Communications] |
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| Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.
[Cellular and Molecular Life Sciences] |
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| The authors used multiplex immunofluorescence imaging analysis to characterize melanoma differentiation associated gene 5 (MDA5) expression and distribution in pancreatic tissues obtained from 22 organ donors.
[Frontiers in Immunology] |
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| Scientists showed that APE1 (apurinic/apyrimidinic endonuclease 1), a multifunctional DNA repair enzyme, was a G-quadruplex (G4)-binding protein, and loss of APE1 abrogated the formation of stable G4 structures in cells.
[Nucleic Acids Research] |
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| The biological effects of nuclear receptor subfamily 2 group F member 1 antisense RNA 1 (NR2F1-AS1) and NR2F1 in pancreatic cancer were investigated by in vitro and in vivo experiments.
[Cell Death & Disease] |
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| Investigators demonstrated that autophagy-associated circular RNAs (circRNAs) circ-autophagy related 7 (circATG7) was elevated in pancreatic cancer tissues compared to adjacent tissues.
[Cell Death & Disease] |
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| U2AF homology motif kinase 1 (UHMK1) expression was enhanced in PDAC, and high UHMK1 expression correlated with tumor stage, and lower overall survival.
[Frontiers in Oncology] |
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| Scientists investigated the role of long noncoding RNA HOXD cluster antisense RNA 1 (HOXD-AS1) in pancreatic cancer and its underlying mechanisms.
[Pathology Research and Practice] |
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| The authors summarize the roles and underlying mechanisms of transcription factors in the maintenance of β-cell identity under physiological and type 2 diabetic conditions.
[Journal of Genetics and Genomics] |
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| Investigators focus on the recent development of new clinically validated and novel biomarkers as well as the methods that represent cost-effective alternatives for screening and early diagnosis of type 2 diabetes mellitus.
[Current Diabetes Reports] |
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Better Therapeutics, Inc. announced primary endpoint data from its pivotal trial of BT-001, a first-in-class investigational PDT platform that is designed to use digitally delivered nutritional cognitive behavioral therapy to treat type 2 diabetes.
[Better Therapeutics, Inc. (Business Wire, Inc.)] |
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| | Dana-Farber Cancer Institute – Boston, MA, United States |
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| | Baylor College of Medicine – Houston, TX, United States |
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| | NYU Grossman School of Medicine – New York, NY, United States |
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| | Centre for Genomic Regulation – Barcelona, Spain |
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| | NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
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