 | | Vol. 13.11 – 22 March, 2022 |
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| Investigators showed that pancreatic ductal adenocarcinoma (PDA) cells could activate ketone body metabolism and that β-hydroxybutyrate was an alternative cell-intrinsic or systemic fuel that could promote PDA growth and progression.
[EMBO Journal] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Mouse lines that expressed a gain-of-function mutation in the γ1 AMP-activated protein kinase (AMPK) subunit D316a were generated to examine the effects of chronic AMPK stimulation in the whole body, or selectively in the beta cell.
[Diabetologia] |
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| Scientists found that Notch activation in postnatal β cells impaired glucose-stimulated insulin secretion and glucose intolerance, but also observed a remnant glucose intolerance after doxycycline withdrawal and cessation of Notch activity, associated with a marked disruption of normal islet architecture.
[JCI Insight] |
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| The authors showed that intracellular Ca2+ and reactive oxygen species signals generated by high glucose and cytokine-induced endoplasmic reticulum stress-activated calcineurin/NFATc2 and PI3K/AKT to maintain β-cell identity and function.
[iScience] |
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| To discriminate the role of PFKFB3 from HIF1α in vivo, scientists generated mice with conditional β-cell specific disruption of the Pfkfb3 gene on a human islet pancreatic polypeptide background and a high-fat diet.
[Communications Biology] |
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| Researchers discovered that growth differentiation factor 15 (GDF15) promoted endoplasmic reticulum (ER) stress-induced beta cell apoptosis and that the downregulation of GDF15 has beneficial effects on beta cell survival in diabetes.
[Endocrinology] |
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| Scientists investigated the role of sigma‑1 receptor (Sig-1R) in islet β‑cell proliferation and examined the effects of Sig‑1R on islet β‑cell injury under lipotoxic conditions.
[Molecular Medicine Reports] |
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| Investigators reported that USP49 stability was governed by F-box protein 45 (Fbxo45)-mediated ubiquitination and was enhanced by the absence of Fbxo45.
[Cell Death & Disease] |
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| Researchers employed MiaPaCa-2 and PANC-1 cell lines and investigated how urokinase-plasmin activator (uPA) regulated epithelial-mesenchymal transition and metastasis in pancreatic cancer, and presented a novel approach aimed at inhibiting uPA in pancreatic cancer.
[Phytomedicine] |
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| The authors discovered that epidermal growth factor receptor affected major histocompatibility complex class I mRNA and protein expression by human pancreatic cancer cell lines.
[Immunologic Research] |
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| Investigators describe recent advances in the understanding of pancreatic ductal metaplasia biology with a focus on its underlying cellular and molecular mechanisms, and in biomarker discovery with clinical implications for the management of pancreatic regeneration and tumorigenesis.
[Cellular Oncology] |
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| AIM ImmunoTech, Inc. announced it has received notification from the FDA that the FDA’s Clinical Hold on AIM’s investigational new drug (IND) application for a Phase II study of Ampligen as a therapy for locally advanced pancreatic cancer has been lifted and the company may proceed with the study.
[AIM ImmunoTech Inc.] |
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| May 1, 2022 – May 4, 2022
Riviera Maya, Mexico |
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| | TUM University Hospital Klinikum rechts der Isar – München, Germany |
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| | Dana-Farber Cancer Institute – Boston, MA, United States |
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| | Baylor College of Medicine – Houston, TX, United States |
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| | Dana-Farber Cancer Institute – Boston, MA, United States |
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| | Centre for Genomic Regulation – Barcelona, Spain |
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