 | | Vol. 13.13 – 5 April, 2022 |
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| In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented an improved stimulation index of glucose-induced insulin secretion.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported the identification of two RNA aptamers that specifically and selectively recognized mouse and human β cells.
[Nature Communications] |
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| The authors assessed the effects of short-term 1,5-anhydro-D-glucitol stimulation on insulin secretion in both ex vivo and in INS-1E rat-derived cells in vitro.
[Journal of Pharmacological Sciences] |
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| Investigators systematically dissected PDAC intrinsic mechanisms of immune evasion by in vitro and in vivo CRISPR screening, and identified Vps4b and Rnf31 as essential factors required for escaping CD8+ T cell killing.
[Nature Communications] |
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| Scientists determined if patient-derived organoids (PDOs) could be used to personalize poly-chemotherapy regimens by pharmacotyping of treatment-naïve and post neoadjuvant chemotherapy PDAC PDOs.
[Journal of Pathology] |
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| The authors developed a tumor-chip device engineered to mimic the PDAC tumor microenvironment by incorporating patient-derived organoids and stromal cells, specifically pancreatic stellate cells and macrophages.
[Microsystems & Nanoengineering] |
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| Researchers evaluated and confirmed the promising anti-tumor activity of olean-28,13β-lactam (B28) in vitro. RNA-seq profile indicated that multiple metabolic pathways were interrupted in B28 treated pancreatic adenocarcinoma cells.
[Cancer Cell International] |
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| Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.
[Scientific Reports] |
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| Scientists investigated the molecular mechanisms of zinc‑finger protein 217 in pancreatic carcinoma progression.
[Molecular Medicine Reports] |
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| The authors highlight the importance of studying pancreatic β-cell expansion and functional maturation signaling pathways and epigenetic programs to understand the causes of different forms of diabetes and to permit the design of novel therapeutic strategies.
[Trends in Endocrinology and Metabolism] |
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| Investigators discuss the contributions of external, intrinsic, and paracrine factors in pancreatic β-, α-, and δ-cell secretion across the full spectrum of physiological and pathophysiological environments.
[American Journal of Physiology-Endocrinology and Metabolism] |
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| AVM Biotechnology, LLC, announced that it has been awarded a Phase II Small Business Innovation Research (SBIR) grant which will allow the company to pursue additional research in the use of AVM0703 as a monotherapy and combination therapy to reverse recent onset and established Type 1 Diabetes.
[AVM Biotechnology, LLC] |
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| Fractyl Health announced that the company has received approval from the FDA for an Investigational Device Exemption (IDE) to begin its Revitalize-2 pivotal study.
[Fractyl Health, Inc.] |
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| May 25, 2022 – May 29, 2022
Lyon, France |
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| | Helmholtz Munich – Tübingen, Germany |
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| | Princess Margaret Cancer Centre – Toronto, Ontario, Canada |
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| | Munich Technical University – München, Germany |
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| | University of Southern Denmark – Odense M, Denmark |
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| Baylor College of Medicine – Houston, Texas, United States |
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