Pancreatic Cell News Volume 13.14 | Apr 12 2022

    By
    Justin.choi
    -
    0
    113







    2022-04-12 | PACN 13.14


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.14 – 12 April, 2022
    TOP STORY

    Multidimensional Chromatin Profiling of Zebrafish Pancreas to Uncover and Investigate Disease-Relevant Enhancers

    Scientists combined epigenetic assays with reporter assays in zebrafish and human pancreatic cells to identify interspecies functionally equivalent cis-regulatory elements, regardless of sequence conservation.
    [Nature Communications]

    Full Article
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Human Pancreatic Microenvironment Promotes β-Cell Differentiation via Non-canonical WNT5A/JNK and BMP Signaling

    Researchers uncovered unique factors that guided in vitro development of endocrine progenitors, with WNT5A markedly improving human β-cell differentiation.
    [Nature Communications]

    Full Article

    Laminin Matrix Regulates Beta-Cell FGFR5 Expression to Enhance Glucose-Stimulated Metabolism

    Using a genetically encoded sensor for NADPH/NADP+ redox state, investigators showed that overexpression of FGFR5 enhanced glucose-stimulated NADPH metabolism in beta-cell lines as well as mouse and human beta-cells
    [Scientific Reports]

    Full Article

    Efficacy of Glucagon-Like Peptide-1 and Estrogen Dual Agonist in Pancreatic Islets Protection and Pre-Clinical Models of Insulin-Deficient Diabetes

    Scientists studied the efficacy of a glucagon-like peptide-1 (GLP-1) and estrogen dual agonist (GLP1-E2) in pancreatic islet protection. GLP1-E2 provided superior protection from insulin-deficient diabetes induced by multiple low-dose streptozotocin and by the Akita mutation in mice than a GLP-1 monoagonist.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Pancreatic Ductal Adenocarcinoma Cells Employ Integrin α6β4 to Form Hemidesmosomes and Regulate Cell Proliferation

    To identify the integrin adhesion systems that operate in PDAC, the authors analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.
    [Matrix Biology]

    Full Article

    Identification of Distinct Slow Mode of Reversible Adaptation of Pancreatic Ductal Adenocarcinoma to the Prolonged Acidic pH Microenvironment

    PDAC cells used a distinct and lengthy process of reversible adaptive plasticity centered on the early fast and later slow mitochondrial network dynamics and metabolic adjustment.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    ZMAT1 Acts as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Inducing SIRT3/p53 Signaling Pathway

    Multiple bioinformatics analyses were used to evaluate zinc finger matrin-type 1 (ZMAT1) expression and potential role in PDAC. In vitro and in vivo studies were performed to assess the effects of ZMAT1 on PDAC cells growth.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction

    Pancreatic cancer cells were used to verify the in vitro and in vivo effects of solasonine. Metabolomics were used to evaluate its underlying mechanisms. Solasonine promoted PANC-1 and CFPAC-1 cell apoptosis while inhibiting their proliferation, migration and invasion.
    [Frontiers in Oncology]

    Full Article

    m6A RNA Demethylase FTO Promotes the Growth, Migration and Invasion of Pancreatic Cancer Cells through Inhibiting TFPI-2

    Knockdown of fat mass and obesity-related protein (FTO) increased m6A methylation of TFPI-2 mRNA in pancreatic cancer (PC) cells, which increased mRNA stability via the m6A reader YTHDF1, resulting in up-regulation of TFPI-2 expression, and inhibited PC proliferation, colony formation, sphere formation, migration and invasion in vitro.
    [Epigenetics]

    Abstract
    Enter your best cell image by April 28 for a chance to win!
    REVIEWS

    Pancreatic Cancer: Pathogenesis, Screening, Diagnosis and Treatment

    Investigators discuss the pathogenesis of PDAC, including molecular alterations in tumor cells, cellular alterations in the tumor microenvironment, and population-level risk factors.
    [Gastroenterology]

    Abstract

    Subtyping for Pancreatic Cancer Precision Therapy

    The authors summarize the current approaches to classification of pancreatic cancer, and highlight the feasibility and potential defects of their application in precision therapy.
    [Trends in Pharmacological Sciences]

    Abstract

    β-Cell Mitochondria in Diabetes Mellitus: A Missing Puzzle Piece in the Generation of hPSC-Derived Pancreatic β-Cells?

    Investigators highlight the role of mitochondria in metabolism secretion coupling in the β-cells and summarize the evidence accumulated for the implication of mitochondria in β-cell dysfunction in diabetes mellitus.
    [Journal of Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    MediciNova Announces Plans for a Phase II Trial of MN-001 (tipelukast) in NAFLD with Type 2 Diabetes Mellitus and Hypertriglyceridemia

    MediciNova, Inc. announced that the FDA has completed its review of a Phase II clinical trial protocol to evaluate MN-001 for the treatment of patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus, and hypertriglyceridemia.
    [MediciNova, Inc.]

    Press Release
    FEATURED EVENT

    ISSCR 2022 Annual Meeting

    June 15 – 18, 2022
    San Francisco, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Professor – Experimental Diabetes Research

    Uppsala University – Uppsala, Sweden

    PhD Position – Tumor Immunology

    University Hospital Carl Gustav Carus Dresden – Dresden, Germany

    Senior Scientist – Islet Biology

    Helmholtz Munich – Tübingen, Germany

    Postdoctoral Fellow – Pancreatic Cancer Evolution

    Princess Margaret Cancer Centre – Toronto, Ontario, Canada

    PhD Student Positions – Pancreatic Cancer Research and Bioinformatics

    TUM University Hospital Klinikum rechts der Isar – München, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pancreatic Cell News Twitter