 | | Vol. 13.16 – 26 April, 2022 |
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| Investigators performed studies with Hnf1b–CreERT2; Ptenf/f; Arid1af/f mice and investigated the consequence of genetic deletion of Arid1a in adult pancreatic ductal cells.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed the efficacy of genesets describing the identity of human α-, β-, γ- and δ-cells to outline cell identity changes and unraveled some of their underlying genetic mechanisms, whether during embryonic pancreas development or in experimental setups aimed at developing glucose-responsive insulin-secreting cells.
[Nature Communications] |
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| Researchers investigated the changes of lysosomal Ca2+ by mitochondrial or metabolic stress that could modulate transcription factor EB (TFEB) activation and, additionally, the role of TFEB-induced mitophagy in β-cell function.
[Autophagy] |
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| The authors reported on a protocol enabling a long-term expansion of human pancreatic progenitors in a defined medium on fibronectin, in the absence of feeder layers.
[Stem Cell Reports] |
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| Investigators integrated the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data and the results of drug sensitivity analysis of 283 epigenetic-related chemicals and 5 chemotherapeutic drugs.
[Nature Communications] |
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| Scientists characterized the protein interactome of the p53R273H mutant in cells derived from PDAC, where p53R273H was the most frequent p53 mutant.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers screened the differentially expressed circRNAs in human pancreatic cancer cell lines and gemcitabine resistant pancreatic cancer cell lines and discovered a new gemcitabine resistant-related molecule in pancreatic cancer.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors investigated the mechanism that HGF/c-Met pathway facilitated the perineural invasion of pancreatic cancer.
[Cell Death & Disease] |
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| Scientists explored the impact of trametinib and/or JQ1 on KRAS mutant pancreatic cancer and addressed the potential mechanism.
[Aging] |
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| Investigators summarize recent advances in the clinical diagnosis and treatment of pancreatic cancer, emphasizing the enormous potential for operating microbiota in pancreatic cancer treatment.
[Biochimica et Biophysica Acta-Reviews On Cancer] |
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| Diagnos Inc. announced the extension of its contract for the follow-up of Diabetic patients under treatment with drugs included in its therapeutic portfolio.
[Diagnos, Inc.] |
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| SOTIO Biotech announced that it has dosed the first patient in its Phase I/II CLAUDIO-01 trial of SOT102 in patients with gastric and pancreatic cancer.
[SOTIO Biotech, Inc.] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | City of Hope – Duarte, California, United States |
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| | City of Hope – Duarte, California, United States |
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| | Helmholtz Munich – Dresden, Germany |
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| | Helmholtz Munich – Tübingen, Germany |
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| | Princess Margaret Cancer Centre – Toronto, Ontario, Canada |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
