Pancreatic Cell News Volume 13.19 | May 17 2022

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    2022-05-17 | PACN 13.19


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.19 – 17 May, 2022
    TOP STORY

    Rapid Acceleration of KRAS-Mutant Pancreatic Carcinogenesis via Remodeling of Tumor Immune Microenvironment by PPARδ

    Investigators showed that peroxisome proliferator-activated receptor-delta (PPARδ), a lipid nuclear receptor, was upregulated in pancreatic intraepithelial neoplasia lesions in humans and mice.
    [Nature Communications]

    Full Article
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    Cargo Receptor Surf4 Regulates Endoplasmic Reticulum Export of Proinsulin in Pancreatic β-Cells

    Scientists demonstrated that Surf4, a cargo receptor homolog, regulated the endoplasmic reticulum (ER) export of proinsulin via its recruitment to ER exit sites.
    [Communications Biology]

    Full Article

    St13 Protects against Disordered Acinar Cell Arachidonic Acid Pathway in Chronic Pancreatitis

    St13, a co-chaperone protein, was investigated whether it constituted a novel regulatory target in chronic pancreatitis.
    [Journal of Translational Medicine]

    Full Article

    A p300/GATA6 Axis Determines Differentiation and Wnt Dependency in Pancreatic Cancer Models

    Researchers performed in vivo CRISPR screens in PORCN inhibitor-sensitive RNF43-mutant pancreatic cancer xenografts.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    HOXA10 Promote Pancreatic Cancer Progression via Directly Activating Canonical NF-κB Signaling Pathway

    Immunohistochemistry assays were applied and demonstrated the relationship between homeobox A10 (HOXA10) expression and PDAC progression.
    [Carcinogenesis]

    AbstractGraphical Abstract

    RyR2/IRBIT Regulates Insulin Gene Transcript, Insulin Content, and Secretion in the Insulinoma Cell Line INS-1

    Insulin content, basal and 7.5 mM glucose-stimulated insulin secretion were reduced in RyR2KO and IRBITKO cells compared to controls.
    [Scientific Reports]

    Full Article

    Terpenoids from Nardostachys jatamansi and Their Cytotoxic Activity against Human Pancreatic Cancer Cell Lines

    Compound epoxynardosinone exhibited significant cytotoxicity against CAPAN-2 cell lines with IC50 value of 2.60 ± 1.85 μM. 1-Hydroxylaristolone displayed comparable cytotoxicity on CFPAC-1 cell lines, compared to Taxol.
    [Phytochemistry]

    AbstractGraphical Abstract

    Coix Seed Oil Regulates Mitochondrial Functional Damage to Induce Apoptosis of Human Pancreatic Cancer Cells via the PTEN/PI3K/AKT Signaling Pathway

    Researchers investigated the possible mechanism of coix seed oil induction of pancreatic cancer cell apoptosis and regulating mitochondrial functional damage.
    [Molecular Biology Reports]

    AbstractGraphical Abstract

    SQLE Inhibition Suppresses the Development of Pancreatic Ductal Adenocarcinoma and Enhances Its Sensitivity to Chemotherapeutic Agents In Vitro

    Investigators explored the function of seven important enzymes involved in cholesterol biosynthesis, especially squalene epoxidase (SQLE) in PDAC therapy.
    [Molecular Biology Reports]

    Abstract
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    REVIEWS

    The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer

    Scientists review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment.
    [Frontiers in Oncology]

    Full Article

    The Roles of MicroRNA in Pancreatic Cancer Progression

    The authors review the recent developments in miRNAs and their target role in the development, metastasis, migration, and invasion of PDAC.
    [Cancer Investigation]

    Abstract
    INDUSTRY AND POLICY NEWS

    NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes

    NexImmune, Inc., Yale and JDRF have begun a two-year project to explore the use of NexImmune’s AIM nanoparticles in combination with an anti-CD3 mAb to tolerize, deplete or modulate diabetes antigen-specific T cells.
    [NexImmune, Inc.]

    Press Release

    BC Researchers Launching Clinical Trial for First Genetically Engineered Stem Cell-Based Therapy for Type 1 Diabetes

    Researchers from the UBC Faculty of Medicine and Vancouver Coastal Health have received $1 million from Canada’s Stem Cell Network to conduct research and a clinical trial for one of the world’s first genetically engineered cell replacement therapies for type 1 diabetes.
    [The University of British Columbia]

    Press Release
    FEATURED EVENT

    Cell UK

    7 – 8 November, 2022
    London, England, United Kingdom

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    JOB OPPORTUNITIES

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    Postdoctoral Position – Clinical Proteomics

    Steno Diabetes Center – Herlev, Denmark

    Postdoctoral Fellow – Prostate/Pancreatic Cancer

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Faculty Position – Gastroenterology Pancreas Disease Research

    Cincinnati Childrens – Cincinnati, Ohio, United States

    Researcher Position – Mouse Genetics, Diabetes and Cell Regeneration

    DiogenX – Nice, France

    > See All Jobs

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