Pancreatic Cell News Volume 13.21 | May 31 2022

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    2022-05-31 | PACN 13.21


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.21 – 31 May, 2022
    TOP STORY

    Lysosomal Lipid Switch Sensitises to Nutrient Deprivation and mTOR Targeting in Pancreatic Cancer

    Scientists found that loss of PI3K-C2γ prevented mechanistic target of rapamycin complex 1 (mTORC1) inactivation and triggered tumor vulnerability to RAD001 and BPTES/CB-839.
    [Gut]

    Full Article
    Explore Antibodies for Epithelial Cell Markers
    PUBLICATIONSRanked by the impact factor of the journal

    Glyoxalase 1 Knockdown Induces Age-Related β-Cell Dysfunction and Glucose Intolerance in Mice

    Researchers showed that methylglyoxal accumulation induced an age-dependent impairment of glucose tolerance and glucose-stimulated insulin secretion in mice knockdown for glyoxalase 1.
    [EMBO Reports]

    AbstractGraphical Abstract

    Local Activation of Focal Adhesion Kinase Orchestrates the Positioning of Presynaptic Scaffold Proteins and Ca2+ Signaling to Control Glucose-Dependent Insulin Secretion

    Investigators demonstrated that the organotypic pancreatic slice, when compared with isolated islets, preserved intact β-cell structure and enhanced glucose-dependent Ca2+ responses and insulin secretion.
    [eLife]

    Full Article

    Functional IKK/NF-κB Signaling in Pancreatic Stellate Cells Is Essential to Prevent Autoimmune Pancreatitis

    The authors showed a protective immunomodulatory function of NF-κB in pancreatic stellate cells (PSCs). Conditional deletion of NEMO in PSCs led to spontaneous pancreatitis with elevated circulating IgM, IgG and antinuclear autoantibodies within 18 weeks.
    [Communications Biology]

    Full Article

    Prosaposin, Tumor-Secreted Protein, Promotes Pancreatic Cancer Progression by Decreasing Tumor-Infiltrating Lymphocytes

    Scientists employed glycoproteomics with tandem mass tag labeling to investigate the culture media of three human PDAC cell lines, and attempted to identify the key secreted proteins from PDAC cells.
    [Cancer Science]

    Abstract

    KIF11 Manipulates SREBP2-Dependent Mevalonate Cross Talk to Promote Tumor Progression in Pancreatic Ductal Adenocarcinoma

    Investigators elucidated the oncogenic functions of kinesin family member 11 (KIF11) in stimulating cholesterol metabolism, thereby driving PDAC progression.
    [Cancer Medicine]

    Full Article

    Increased Expression of SPRR1A Is Associated with a Poor Prognosis in Pancreatic Ductal Adenocarcinoma

    Researchers elucidated the expression of small proline-rich protein 1A (SPRR1A) in PDAC and its effect on the prognosis and malignant behavior of PDAC.
    [PLoS One]

    Full Article

    Acquired Chemoresistance Drives Spatial Heterogeneity, Chemoprotection and Collective Migration in Pancreatic Tumor Spheroids

    The authors showed that the spontaneous emergence of chemoresistance in a cancer cell population exposed to the selective pressure of a chemotherapeutic agent could result in the emergence of collective cell behavior, including cell-sorting, chemoprotection, and collective migration.
    [PLoS One]

    Full Article
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Achievements, Prospects and Challenges in Precision Care for Monogenic Insulin-Deficient and Insulin-Resistant Diabetes

    The subgroup of diabetes caused by single gene defects provides the best example to date of the vision of ‘precision diabetes’. Monogenic diabetes may be divided into primary pancreatic beta-cell failure and primary insulin resistance.
    [Diabetologia]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Biorep Technologies, Inc. Joins the Tetra Partner Network to Accelerate Research into Stem-Cell Derived Insulin to Cure Diabetes

    TetraScience announced that Biorep Technologies, Inc., the leading provider of scientific instruments that help pharmaceutical companies and leading universities research cures for Type 1 and Type 2 diabetes, has joined the Tetra Partner Network.
    [TetraScience, Inc.]

    Press Release
    FEATURED EVENT

    Channels in Context: Structure and Function of Ion Channels in Macromolecular Complexes and Native Cells

    September 7 – 11, 2022
    Woods Hole, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Microenvironment in Metastasis

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Staff Scientist – Obesity and Metabolic Diseases

    National Institutes of Health – Bethesda, Maryland, United States

    Tenure Track Scientist – Metabolism

    Rutgers Robert Wood Johnson Medical School – New Brunswick, New Jersey, United States

    Lab Associate – Human Islet Isolation

    City of Hope – Duarte, California, United States

    Principal Investigator – Interdisciplinary Research in Biology

    CNRS – Paris, France

    > See All Jobs

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