Pancreatic Cell News Volume 13.22 | Jun 7 2022

June 7, 2022

2022-06-07 | PACN 13.22

Pancreatic Cell News by STEMCELL Technologies

Vol. 13.22 – 7 June, 2022

TOP STORY

Cancer-Cell-Secreted Extracellular Vesicles Suppress Insulin Secretion through miR-122 to Impair Systemic Glucose Homeostasis and Contribute to Tumour Growth

Investigators showed that breast cancer-derived extracellular vesicles suppressed pancreatic insulin secretion to impair glucose homeostasis.
[Nature Cell Biology]

Abstract Press Release

Watch a webinar on using patient-derived iPS cells to model diabetes.

PUBLICATIONSRanked by the impact factor of the journal

DIABETES & PANCREATITIS

IL18 Signaling Causes Islet β Cell Development and Insulin Secretion via Different Receptors on Acinar and β Cells

Researchers reported that interleukin-18 (IL18) was expressed on islet α cells, Na-Cl co-transporter on β cells, and IL18r on acinar cells in human and mouse pancreases.
[Developmental Cell]

Abstract Graphical Abstract

Alternative Splicing Encodes Functional Intracellular CD59 Isoforms That Mediate Insulin Secretion and Are Down-Regulated in Diabetic Islets

Investigators demonstrated the existence of CD59 splice variants in human pancreatic islets, which have unique C-terminal domains replacing the GPI-anchoring signal sequence.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

Neuropeptide Neuromedin B Does Not Alter Body Weight and Glucose Homeostasis nor Does It Act as an Insulin-Releasing Peptide

The authors evaluated the role of neuromedin B on basal and glucose-stimulated insulin secretion in mice and humans.
[Scientific Reports]

Full Article

PANCREATIC CANCER

Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk

Scientists presented a genome-wide splicing quantitative trait locus analysis to identify single-nucleotide polymorphisms that controlled mRNA splicing in 176 PDAC samples from The Cancer Genome Atlas.
[Cancer Research]

Abstract
Graphical Abstract

The LCK-14-3-3ζ-TRPM8 Axis Regulates TRPM8 Function/Assembly and Promotes Pancreatic Cancer Malignancy

Researchers revealed the importance of transient receptor potential melastatin (TRPM8) phosphorylation at Y1022 in the proliferation, migration, and tumorigenesis of pancreatic cancer cells.
[Cell Death & Disease]

Full Article

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

REVIEWS

The Burden and Risks of Emerging Complications of Diabetes Mellitus

The authors summarize information from systematic reviews and major cohort studies regarding emerging complications of type 1 and type 2 diabetes mellitus to identify and quantify associations, highlight gaps and discrepancies in the evidence, and consider implications for the future management of diabetes mellitus.
[Nature Reviews Endocrinology]

Full Article

Thiosemicarbazones Reprogram Pancreatic Cancer Bidirectional Oncogenic Signaling between Cancer Cells and Stellate Cells to Suppress Desmoplasia

Scientists discuss the development of the di-2-pyridylketone thiosemicarbazones that overcomes bidirectional oncogenic signaling between pancreatic cancer cells and pancreatic stellate cells, which is critical for desmoplasia development.
[Future Medicinal Chemistry]

Abstract

INDUSTRY AND POLICY NEWS

Legend Biotech Announces US FDA Clearance of IND Application for Solid Tumor CAR-T, LB1908 for Relapsed or Refractory Gastric, Esophageal and Pancreatic Cancers

Legend Biotech Corporation announced that the US FDA has cleared its investigational new drug (IND) application to evaluate LB1908 in a Phase I clinical trial in the United States.
[Legend Biotech Corporation]

Press Release

FEATURED EVENT

Pancreatic Cell News Volume 13.22 | Jun 7 2022

Cancer-Cell-Secreted Extracellular Vesicles Suppress Insulin Secretion through miR-122 to Impair Systemic Glucose Homeostasis and Contribute to Tumour Growth

IL18 Signaling Causes Islet β Cell Development and Insulin Secretion via Different Receptors on Acinar and β Cells

Alternative Splicing Encodes Functional Intracellular CD59 Isoforms That Mediate Insulin Secretion and Are Down-Regulated in Diabetic Islets

Neuropeptide Neuromedin B Does Not Alter Body Weight and Glucose Homeostasis nor Does It Act as an Insulin-Releasing Peptide

Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk

The LCK-14-3-3ζ-TRPM8 Axis Regulates TRPM8 Function/Assembly and Promotes Pancreatic Cancer Malignancy

The Burden and Risks of Emerging Complications of Diabetes Mellitus

Thiosemicarbazones Reprogram Pancreatic Cancer Bidirectional Oncogenic Signaling between Cancer Cells and Stellate Cells to Suppress Desmoplasia

Legend Biotech Announces US FDA Clearance of IND Application for Solid Tumor CAR-T, LB1908 for Relapsed or Refractory Gastric, Esophageal and Pancreatic Cancers

EHA-SWG Scientific Meeting on Integrated Cell Tracking in Oncohematology

> See All Events

Postdoctoral Fellow – Cancer Immunology & Genomics

Postdoctoral Fellow – Tumor Microenvironment

PhD Position – Pancreatic Beta Cell Biology and Diabetes

Postdoctoral Position – Synthetic Biology and Regenerative Medicine

PhD Candidate – Cellular and Molecular Mechanisms of Cancer

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