 | | Vol. 13.23 – 14 June, 2022 |
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| Scientists demonstrated a targetable role of MAP kinase-interacting serine/threonine kinase 2 (MNK2)-controlled translation in β-cell regeneration, a role that warrants further investigation in diabetes.
[Nature Chemical Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Divergence in the metabolic fingerprints of rat pancreatic INS-1 β-cells were systematically captured with regard to ten individual essential amino acid availability.
[Scientific Data] |
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| Researchers reported that oxidative stress-driven reduced/oxidized glutathione loss and proteasomal degradation of glutathione peroxidase 4 promoted ferroptotic-like cell damage through increased lipid peroxidation.
[Translational Research] |
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| The authors investigated the effects of glucagon receptor antagonism on β-cell neogenesis in type 2 diabetic mice, and explored the origins of the neogenic β-cells.
[iScience] |
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| Investigators determined the mechanism by which the sodium glucose co-transporter 2 inhibitor, luseogliflozin, preserved pancreatic beta-cell mass and function in db/db mice.
[Scientific Reports] |
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| Leveraging in silico, in vitro, and in vivo models of human and murine PDAC, researchers discovered a novel intersection between KRAS-TP53 co-altered transcriptomes, TP63-defined squamous trans-differentiation, and myeloid-cell migration into the tumor microenvironment.
[Oncogene] |
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| Scientists examined the essential role and molecular mechanisms of laminin-5 gamma-2 in the tumorigenesis of PDAC.
[Cellular and Molecular Life Sciences] |
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| Researchers reported monolayer cancer cell models wherein the human non-small cell lung carcinoma (NSCLC) cell line H2228 and pancreatic cancer cell line AsPC-1 could be reversibly induced to a quiescent state under hypoxic and serum-starved conditions.
[Scientific Reports] |
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| The authors showed that allosteric inhibitors of mutant isocitrate dehydrogenase 1 (mIDH1) were potent wild-type IDH1 inhibitors under conditions present in the tumor microenvironment.
[Nature Cancer] |
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| The identification of potential and clinically applicable biomarker is momentous to improve the overall survival rate and positively ameliorate the prognosis of patients with pancreatic carcinoma.
[Cell Death Discovery] |
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| Eledon Pharmaceuticals, Inc. announced that the US FDA has granted orphan drug designation to tegoprubart for the prevention of allograft rejection in pancreatic islet cell transplantation.
[Eledon Pharmaceuticals, Inc.] |
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| Three grants awarded to Monash University researchers total more than $11.7 million and cover critical health issues including diabetes, antimicrobial resistance, epilepsy, and intensive care.
[Monash University] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Uppsala University – Uppsala, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | La Jolla Institute for Immunology – La Jolla, California, United States |
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