 | | Vol. 13.31 – 9 August, 2022 |
| |
|
|
| The authors showed that pancreas-derived mesenchymal stem cells were capable of regenerating exocrine pancreas when implanted into the kidney capsule of mice with streptozotocin–induced diabetes.
[Science Translational Medicine] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| By internalizing a subset of plasma membrane proteins at the front domain, including α6β4 integrins, Syt13 modulated cell-matrix adhesion and allowed efficient endocrine cell egression.
[Nature Communications] |
|
|
|
| Single cell RNA-sequencing analysis of islets from type 1 diabetes patients indicated severe deregulation of the chronic stress-adaptation program and revealed novel biomarkers of diabetes progression.
[Nature Communications] |
|
|
|
| Scientists demonstrated that HNF1A-deficient β-cells displayed impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels in association with a reduction in CACNA1A expression, and accumulation of abnormal insulin granules in association with SYT13 down-regulation.
[Communications Biology] |
|
|
|
| Investigators reported that single-dose administration of imeglimin significantly augmented insulin secretion in response to glucose from islets isolated from non-diabetic mice.
[Scientific Reports] |
| |
|
|
| The authors demonstrated that blocking either CD9 or p38 MAPK signaling impaired CD9+ annexin A6 extracellular vesicle–induced cell migration and epithelial-to-mesenchymal transition in PDAC cells.
[Science Signaling] |
|
|
|
| CD44 promoter activity and its interactive EMT-related transcription factors were evaluated by luciferase reporter assay and chromatin immunoprecipitation assay.
[Cell Death & Disease] |
|
|
|
| Researchers discovered that gemcitabine upregulated the expression of cancer susceptibility candidate 9 (CASC9) in a dose-dependent manner, partially via induction of reactive oxygen species, whereas inhibition of CASC9 expression enhanced gemcitabine-induced oxidative stress and apoptosis in pancreatic cancer cells.
[Cell Biology and Toxicology] |
|
|
|
| Scientists demonstrated that Zinc finger protein 655 (ZNF655) knockdown inhibited the biological progression of pancreatic cancer cells, which was characterized by weaken proliferation, enhanced apoptosis, arrested cell cycle in G2, impeded migration, and suppressed tumor growth.
[Oncogenesis] |
|
|
|
| The authors verified that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species levels that suppressed tumor growth.
[Journal of Biochemical and Molecular Toxicology] |
|
|
|
| Investigators demonstrated that K73-03 effectively inhibited the cell proliferation of pancreatic cells, and induced apoptosis and autophagy of ASPC-1 cells in a dose-dependent manner.
[Cell Biology International] |
|
|
|
|
| High-content screening has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules.
[Drug Discovery Today] |
|
|
|
|
| In 2022, 25 research grants have been awarded – including 16 newly awarded grants and nine extensions to support next steps of promising projects – totaling a record $10.5 million.
[Pancreatic Cancer Action Network] |
|
|
|
| The WITec Paper Awards 2022 have been given to scientists from the US, Germany and China, recognizing their work in cement chemistry, pharmacy, and methane hydrate chemistry.
[Oxford Instruments] |
|
|
|
|
| October 20 – 21, 2022
Turin, Italy |
|
|
|
|
|
| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
|
|
|
| | Northwestern University – Chicago, Illinois, United States |
|
|
|
| | CRUK Manchester Institute – Manchester, United Kingdom |
|
|
|
| | Cedars-Sinai – Los Angeles, California, United States |
|
|
|
| | University of California, San Francisco – San Francisco, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
