 | | Vol. 13.32 – 16 August, 2022 |
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| Researchers reported that that β cell-specific genetic ablation of E2f1 impaired glucose homeostasis associated with decreased expression of the Glp-1 receptor (Glp1r) in E2f1β−/− pancreatic islets.
[Cell Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified miR-190 as a candidate regulator that could effectively restore insulin expression in NIT-1 cells under high-glucose stimulation.
[Peerj] |
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| Investigators reported that cerulein increased phospho‑specific forms of JAK2 and STAT3, and mRNA and protein expression of IL‑6, but decreased cytokine signaling 3 (SOCS3) levels in AR42J cells.
[Molecular Medicine Reports] |
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| Scientists reported that increased proliferation of FGFR4-depleted PDAC cells correlated with hyperactivation of the mTORC1 pathway both in vitro and in vivo.
[Oncogene] |
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| Using gene knockout and pharmacological inhibition of cyclin-dependent kinase 7 (CDK7) by THZ1, the authors reported cell cycle arrest, apoptosis induction, and DNA damage through the STAT3-MCL1-CHK1 axis.
[Journal of Experimental & Clinical Cancer Research] |
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| A 3D model representing human pancreas/duct carcinoma and human lung adenocarcinoma was designed and applied as a clear proof of the remarkable therapeutic potential of a new coordination polymer n·3nH2O.
[Journal of Medicinal Chemistry] |
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| Using in vivo and in vitro experiments, the authors demonstrated that abnormal expression of (CUGBP) Elav-like family member 2 (CELF2) affected the stemness, apoptosis, and proliferation of pancreatic cancer cells.
[Cell and Bioscience] |
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| Using Ingenuity Pathway Analysis analysis on the differentially expressed genes, researchers determined that EIF2 signaling was the core pathway regulating the development of PDAC.
[Scientific Reports] |
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| Investigators demonstrated that pipernonaline, one of the components of the spice pepper, preferentially reduced the survival of human pancreatic cancer PANC-1 cells under nutrient-deprived conditions.
[Bioorganic & Medicinal Chemistry] |
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| The authors overview the status of the field of human islet research, highlight the challenges and propose actions that could accelerate research progress and increase understanding of type 2 diabetes to slow its pandemic spreading.
[Nature Metabolism] |
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| The National Institute of Diabetes and Digestive and Kidney Disease, part of the National Institutes of Health (NIH), has awarded $4 million to support career advancement for nutrition, obesity and diabetes researchers from underrepresented groups.
[UNC Gillings School Of Global Public Health] |
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| September 15 – September 17, 2022
Dublin, Ireland, United Kingdom |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
| | | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | Northwestern University – Chicago, Illinois, United States |
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| | CRUK Manchester Institute – Manchester, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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