 | | Vol. 13.36 – 13 September, 2022 |
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| Researchers used single-cell RNA sequencing to profile more than 50,000 endocrine cells isolated from healthy human, pig, and mouse pancreatic islets and characterized transcriptional heterogeneity and evolutionary conservation of those cells across the three species.
[Molecular Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators observed that Irisin treatment prevented INS-1 cell apoptosis induced by palmitic acidtreatment and preserved the insulin-secreting function of INS-1 cells in vitro.
[Oxidative Medicine and Cellular Longevity] |
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| Scientists constructed extra-hepatic functional islet tissue by transferring 3D beta cells and GFP labeled mesenchymal stem cell sheets to the subcutaneous site of rats with STZ-induced diabetes.
[Tissue and Cell] |
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| Researchers investigated the therapeutic potential of p53-expressing telomerase-specific oncolytic adenovirus OBP-702 to induce immunogenic cell death and antitumor immune responses in human PDAC cells with different p53 status.
[Molecular Therapy Oncolytics] |
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| Viability, radiosensitization, angiogenesis, migration, colony formation, TUNEL, cell cycle, multicellular tumorsphere induction, and in vivo assays were performed to test the influence of PARP1 inhibition on resistance phenomena and tumor progression.
[Biomedicine & Pharmacotherapy] |
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| Metformin (Met)/Achillea vermicularis (AV) loaded nanofibers were found to be more effective against insulinoma cells in vitro than Met-loaded and AV-loaded nanofibers.
[European Polymer Journal] |
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| Researchers discuss four different types of phenotypic heterogeneity within PDAC, from morphological to metabolic heterogeneity.
[Oncogene] |
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| The authors describe the state of the art in β-cell replacement with a focus on its efficacy and clinical benefits, on the actual limitations and still unmet needs, and on the latest findings and future directions.
[Stem Cells Translational Medicine] |
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| August’s top grants in regenerative medicine include projects on the development of a dynamic double network hydrogel for generating pancreatic organoids from induced pluripotent stem cells.
[RedMedNet] |
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| Funders and publishers are increasingly asking researchers to account for the role of sex in experiments — a requirement that’s contentious and hard to get right.
[Nature News] |
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| January 29 – February 2, 2023
Banff, Alberta, Canada |
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| | Princess Margaret Cancer Centre, University of Toronto – Toronto, Ontario, Canada |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Beckman Research Institute of City of Hope – Duarte, California, United States |
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