Pancreatic Cell News Volume 13.37 | Sep 20 2022

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    2022-09-20 | PACN 13.34


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.37 – 20 September, 2022
    TOP STORY

    Transcription and Splicing Regulation by NLRC5 Shape the Interferon Response in Human Pancreatic β Cells

    Investigators observed by bulk and single-cell RNA sequencing that exposure of human induced pluripotent-derived islet-like cells to IFNα induced the expression of HLA class I, and of other genes involved in antigen presentation, including the transcriptional activator NLRC5.
    [Science Advances]

    Full Article
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    Secretory Autophagy Promotes RAB37-Mediated Insulin Secretion Under Glucose Stimulation Both In Vitro and In Vivo

    Researchers found that the active form of RAB37 increased MAP1LC3/LC3 lipidation and was essential for the promotion of insulin secretion by autophagy, but these phenomena were not observed in rab37 knockout cells or mice.
    [Autophagy]

    Full Article

    Beta-Cell Mass Expansion During Puberty Involves Serotonin Signaling and Determines Glucose Homeostasis in Adulthood

    Investigators showed that puberty was associated with a transient increase in β-cell proliferation in rats and humans of both sexes.
    [JCI Insight]

    AbstractFull Article

    Diabetes Downregulates the Antimicrobial Peptide Psoriasin and Increases E. coli Burden in the Urinary Bladder

    Scientists investigated the effect of diabetes and high glucose on the expression of the antimicrobial peptide psoriasin, and the putative consequences for E. coli urinary tract infection.
    [Nature Communications]

    Full ArticlePress Release

    miR-24-3p Regulates Epithelial–Mesenchymal Transition and the Malignant Phenotype of Pancreatic Adenocarcinoma by Regulating ASF1B Expression

    Based on real-time quantitative PCR and immunohistochemistry, researchers found that anti-silencing function protein 1 homolog B was significantly upregulated in PDAC tissues.
    [Biochemical Genetics]

    Full Article

    YY1 Promotes Pancreatic Cancer Cell Proliferation by Enhancing Mitochondrial Respiration

    Mechanistically, the impairment of mitochondrial oxidative phosphorylation function reduced the generation of aspartate, and resulted in the inhibition of cell proliferation owing to unavailability of aspartate-associated nucleotides.
    [Cancer Cell International]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    Mechanisms of PDAC Subtype Heterogeneity and Therapy Response

    Investigators discuss how two different types of PDAC, basal-like type and classical type, interact with stromal and immune components of the microenvironment to impact prognosis and therapeutic outcomes.
    [Trends in Cancer]

    Abstract

    Alpha-Cells and Therapy of Diabetes: Inhibition, Antagonism or Death?

    The authors review therapeutic approaches targeting alpha cells in diabetes and observations with therapeutics that directly target alpha-cells, highlighting a largely untapped potential for diabetes therapy.
    [Peptides]

    AbstractFull Article
    INDUSTRY AND POLICY NEWS

    Antengene Announces ATG-101 Granted Orphan Drug Designation by the US FDA

    Antengene announced that ATG-101, the company’s novel PD-L1/4-1BB bispecific antibody, has been granted an Orphan Drug Designation by the US FDA for the treatment of pancreatic cancer.
    [Antengene Corp]

    Press Release

    Maike Sander receives 2022 Albert Renold Prize

    The newly appointed scientific director of the Max Delbrück Center is recognized for her pioneering stem cell work in diabetes.
    [Max Delbrück Center]

    Press Release
    FEATURED EVENT

    Till & McCulloch Meetings

    October 3 – 5, 2022
    Vancouver, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellows – Molecular Metabolism

    University of Gothenburg – Gothenburg, Sweden

    Senior Research Scientist – Pancreatic Beta Cells

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    Postdoctoral Fellow – Pancreatic Cancer Evolution

    Princess Margaret Cancer Centre, University of Toronto – Toronto, Ontario, Canada

    Senior Scientist – Stem Cell Biology

    Helmholtz Munich – Neuherberg, Germany

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    > See All Jobs

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