Pancreatic Cell News Volume 13.38 | Sep 27 2022

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    2022-09-27 | PACN 13.38


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.38 – 27 September, 2022
    TOP STORY

    Islet Primary Cilia Motility Controls Insulin Secretion

    Scientists showed that primary cilia in human and mouse pancreatic islets exhibited movement that was required for glucose-dependent insulin secretion.
    [Science Advances]

    Full Article
    ON987CXN-oct-728x90-2022
    PUBLICATIONSRanked by the impact factor of the journal

    Engineering of Immune Checkpoints B7-H3 and CD155 Enhances Immune Compatibility of MHC-I−/− iPSCs for β Cell Replacement

    By profiling the relevant natural killer-activating ligands on induced pluripotent stem cells (iPSCs) during in vitro differentiation into pancreatic β cells, researchers found that they expressed high levels of B7-H3 and CD155.
    [Cell Reports]

    Full ArticleGraphical Abstract

    An EGFR/HER2-Targeted Conjugate Sensitizes Gemcitabine-Sensitive and Resistant Pancreatic Cancer through Different SMAD4-Mediated Mechanisms

    To overcome chemoresistance in PDAC, scientists aimed to study dual-targeting ligand-based lidamycin efficacy when combined with gemcitabine and exploreed its mechanisms of action.
    [Nature Communications]

    Full Article

    FAK Promotes Stromal PD-L2 Expression associated With Poor Survival in Pancreatic Cancer

    Researchers combined CRISPR, shRNA and flow cytometry with mechanistic experiments using a KrasG12Dp53R172H mouse model of pancreatic cancer and analysis of publicly available human PDAC transcriptomic datasets.
    [British Journal of Cancer]

    Full Article

    Azulene Hydrazide-Hydrazones for Selective Targeting of Pancreatic Cancer Cells

    Scientists tested the cytotoxicity of novel azulene hydrazide-hydrazone-based chelators against pancreatic cancer cell lines (MIA PaCa-2, PANC-1, AsPC-1).
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Biomarkers for Pancreatic Cancer Based on Tissue and Serum Metabolomics Analysis in a Multicenter Study

    Investigators sought to identify metabolic features of PDAC and to discover early detection biomarkers for PDAC by tissue and serum metabolomics analysis.
    [Cancer Medicine]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    REVIEWS

    The Evolving View of Thermogenic Fat and Its Implications in Cancer and Metabolic Diseases

    The authors enumerate current knowledge about the origin and physiological functions of thermogenic fat. In addition, they discuss the multiple roles of thermogenic adipocytes in different tumors.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Interplays of Glucose Metabolism and Kras Mutation in Pancreatic Ductal Adenocarcinoma

    Scientists review convergent and diverse metabolic networks related to oncogenic KRAS mutations between PDAC initiation and progression, emphasizing the interplay among oncogenic mutations, glucose metabolic reprogramming, and the tumor microenvironment.
    [Cell Death & Disease]

    Full Article

    Targeting Pancreatic β Cells for Diabetes Treatment

    The authors highlight recent advances toward the development of diabetes therapies that target β cells to enhance proliferation, redifferentiation and protection from cell death and/or enable selective killing of senescent β cells.
    [Nature Metabolism]

    Full Article
    INDUSTRY AND POLICY NEWS

    Guerbet Obtains One Million Euros of Public Funding From Bpifrance for a Project Developing Artificial Intelligence for the Early Detection of Pancreatic Cancer

    Guerbet obtained one million euros of public funding through a call for projects concerning the acceleration strategy in digital health via the France 2030 investment plan.
    [Guerbet]

    Press Release
    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Diabetes Complications and Metabolism

    City of Hope – Duarte, California, United States

    Postdoctoral Fellow – Precision Oncology of Gastrointestinal Cancers

    Beckman Research Institute – Monrovia, California, United States

    Senior Research Scientist – Pancreatic Beta Cells

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    PhD Position – Pancreatic Beta Cell Biology & Diabetes

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Fellows – Molecular Metabolism

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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