 | | Vol. 13.39 – 4 October, 2022 |
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| Scientists reported that PDAC with elevated expression of METTL16, one of the ‘writers’ of RNA N6-methyladenosine modification, may benefit from poly-(ADP-ribose)-polymerase inhibitor treatment.
[Nature Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By using different models of CP established in mice with dysfunctional pancreatic clocks, researchers found that the local clock played an important role in chronic pancreatitis pathology, and genetic or external disruption of the pancreatic clock exacerbated fibrogenesis and exocrine insufficiency.
[Science Translational Medicine] |
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| Investigators reported the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by S961, a pharmacological insulin receptor antagonist.
[Cell Reports] |
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| The authors investigated the transcriptional mechanisms of beta-cell proliferation in response to fatty acids.The islet transcriptome was assessed by single cell RNA-sequencing.
[Diabetes] |
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| By using ISL1-overexpressing bone marrow mesenchymal stem cells (BMSCs) and the subtherapeutic doses of islets for co-transplantation, scientists managed to reduce the apoptosis and improve the survival rate of islet grafts.
[Cellular and Molecular Life Sciences] |
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| | Researchers demonstrated that RNA polymerase II-associated factor 1 (PAF1) co-expressed and interacted with YAP1 specifically in metaplastic ducts of mouse cerulein- or KrasG12D-induced acinar-to-ductal metaplasia and human PDAC, but not in the normal pancreas.
[Cell Death & Disease] |
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| Human pancreatic cancer PANC-1 cells were co-cultured with dorsal root ganglion in vitro. The expression of matrix metalloproteinase-1 (MMP1), epithelial–mesenchymal transition markers, Schwann cell markers, neurotrophic factors, NT-3, and TrkC were measured by qRT-PCR or Western blot.
[Journal of Clinical Laboratory Analysis] |
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| By highlighting recent integrative multi-omics studies in relevant tissues of four distinct complex diseases (type 2 diabetes, osteoarthritis, Alzheimer’s disease, and systemic lupus erythematosus), investigators outline the usefulness of the approach.
[Trends in Genetics] |
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| The authors discuss, and attempt to unify, the major experimental results from over 40 years of literature characterizing the role of gamma aminobutyric acid (GABA) in the islet.
[Frontiers in Endocrinology] |
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| The National Institutes of Health (NIH) has honored RUSH physician scientist Faraz Bishehsari with the Director’s Transformative Research Award, which includes funding for his innovative pancreatic cancer research.
[Rush University] |
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| October 24 – 26, 2022
Madrid, Spain |
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| | University of Illinois Chicago – Chicago, Illinois, United States |
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| | City of Hope – Duarte, California, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Princess Margaret Cancer Centre, University of Toronto – Toronto, Ontario, Canada |
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