 | | Vol. 13.42 – 25 October, 2022 |
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| Investigators identified the importance of signaling between β-cells via the extracellular signal WNT4. They showed heterogeneity in Wnt4 expression, most strikingly in the postnatal maturation period, Wnt4-positive cells, being more mature while Wnt4-negative cells were more proliferative.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | | Researchers showed that inosine monophosphate treatment stimulateD cKit expression, ribosomal S6 activation, granulocyte/monocyte progenitor proliferation, and Gr-1+ granulocyte production in vitro.
[Communications Biology] |
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| The authors assessed the microanatomy of the human pancreas during tumorigenesis within the branching pancreatic ductal system, labeling ten distinct structures to examine heterogeneity and structural transformation during neoplastic progression.
[Frontiers in Endocrinology] |
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| Researchers revealed that chemotherapy upregulated placental growth factor, which directly activated cancer-associated fibroblasts to induce fibrosis-associated collagen deposition in PDAC.
[Nature Communications] |
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| Scientists found that F. nucleatum infection induced both normal pancreatic epithelial cells and PDAC cells to secrete increased amounts of the cytokines GM-CSF, CXCL1, IL-8, and MIP-3α.
[Science Signaling] |
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| Scientists showed that Hernandezine dose-dependently suppressed cell proliferation, promoted autophagy, and induced autophagic death in PDAC cell lines Capan-1 and SW1990.
[Acta Pharmacologica Sinica] |
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| The authors discuss the metabolic pathways that are altered in response to treatment and those that can, in turn, alter treatment efficacy, as well as the role of metabolism in the tumor microenvironment in dictating the therapeutic response in KRAS-driven cancers.
[Science Signaling] |
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| Investigators review the origins and functional diversity of cancer-associated fibroblasts (CAFs), and show how they create a tumour-promoting milieu, focusing on the crosstalk between CAFs, tumor cells, and immune cells in the tumour microenvironment.
[Cell Death & Disease] |
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| The National Cancer Institute has awarded the UNC Lineberger Pancreatic Cancer Center of Excellence a five-year, $10.9 million Pancreatic Cancer Specialized Program of Research Excellence (SPORE) grant intended to further enhance treatment solutions for pancreatic cancer.
[The University of North Carolina] |
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| March 26 – 31, 2023
Ventura, California, United States |
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| | AstraZeneca – Gothenburg, Sweden |
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| | Novo Nordisk – Seattle, Washington, United States |
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| | University of Oxford – Oxford, United Kingdom |
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| | University of Southern Denmark – Odense, Denmark |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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