 | | Vol. 13.44 – 8 November, 2022 |
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| The investigators showed that inhibiting vasoactive intestinal peptide receptor signaling enhanced anti-tumor immunity in murine PDAC models.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that the ARID1A mammalian SWI/SNF complex subunit was a critical regulator of β-cell regeneration.
[Cell Reports] |
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| Human islets, EndoC-βH1 and INS1 832/13 cells were transfected with scramble and EPDR1 siRNAs, or treated with human EPDR1 protein, and glucose-stimulated insulin secretion assessed by ELISA.
[Molecular Metabolism] |
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| Scientists investigated the role of thioredoxin interacting protein in acute pancreatitis when induced by high doses of arginine.
[Cell Death & Disease] |
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| Investigators used a mouse pancreatic organoid model to compare three PD-L1 blocking antibodies in the presence or absence of IFNγ using a metabolic bioanalyzer.
[mAbs] |
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| Following generation of an expression vector for the new PRSS1 variant, scientists compared its expression, secretion, and catalytic activity with already known PRSS1 risk variants in HEK 293T cells.
[Pancreatology] |
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| Overexpression or knockdown of MACC1 in pancreatic cancer cells correspondingly promoted or inhibited pancreatic cancer cell migration and invasion in a MET proto-oncogene receptor tyrosine kinase-independent manner.
[Cell Death & Disease] |
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| Epithelium-specific ETS transcription factor 1 (ESE1) was found to exhibit dual roles in regulation of malignant properties of PDAC cells in that its overexpression promoted cell proliferation, whereas its downregulation enhanced epithelial-mesenchymal transition phenotype.
[Cancer Medicine] |
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| In PDAC cell line, SLC6A14 or SPOCK1 knockdown inhibited cells proliferation, migration, and promoted cells apoptosis.
[Heliyon] |
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| The authors describe the history of glucagon research from the past to the present and suggest some direction to the future of this field.
[Cell Metabolism] |
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| Investigators review the methods developed to generate pancreas organoids in vitro from embryonic, fetal and adult cells, as well as pluripotent stem cells.
[Development] |
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| The FDA commits to exploring alternative methods to replace laboratory animals in developing new drugs and products.
[Nature News] |
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| March 6 – 8, 2023
Paris, France |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | AstraZeneca – Gothenburg, Sweden |
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| | Novo Nordisk – Seattle, Washington, United States |
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