Pancreatic Cell News Volume 13.45 | Nov 15 2022

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    2022-11-15 | PACN 13.45


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 13.45 – 15 November, 2022
    TOP STORY

    Extensive Preclinical Validation of Combined RMC-4550 and LY3214996 Supports Clinical Investigation for KRAS Mutant Pancreatic Cancer

    The authors reported on the combined inhibition of SHP2, upstream of KRAS, using the allosteric inhibitor RMC-4550 and of ERK, downstream of KRAS, using LY3214996.
    [Cell Reports Medicine]

    AbstractFull ArticleGraphical Abstract
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    Altered Glycolysis Triggers Impaired Mitochondrial Metabolism and mTORC1 Activation in Diabetic β-Cells

    Using isolated islets and INS-1 cells, investigators showed that one or more glycolytic metabolites downstream of phosphofructokinase and upstream of GAPDH mediated the effects of chronic hyperglycemia.
    [Nature Communications]

    Full ArticlePress Release

    PAHSAs Reduce Cellular Senescence and Protect Pancreatic Beta Cells From Metabolic Stress through Regulation of Mdm2/p53

    In vitro palmitic acid hydroxy stearic acids (PAHSAs) increased Mdm2 expression, which decreased the stability of p53, a key inducer of senescence-related genes. In addition, PAHSAs enhanced expression of protective genes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    The β-Cell Primary Cilium Is an Autonomous Ca2+ Compartment for Paracrine GABA Signaling

    Researchers used intact mouse pancreatic islets of Langerhans to investigate signaling properties of the primary cilium in insulin-secreting β-cells.
    [Journal of Cell Biology]

    Full Article

    Single-Cell Imaging of α and β Cell Metabolic Response to Glucose in Living Human Langerhans Islets

    Fluorescence Lifetime Imaging Microscopy allowed scientists to measure variations in the NAD(P)H free/bound ratio induced by glucose; immunofluorescence data allowed to identify single α and β cells; finally, matching of the two datasets allowed to assign metabolic shifts to cell identity.
    [Communications Biology]

    Full Article

    Pancreatic Tumor Microenvironmental Acidosis and Hypoxia Transform Gold Nanorods into Cell-Penetrant Particles for Potent Radiosensitization

    Investigators designed gold nanorods with an epilayer that retained stealth properties in circulation but transformed spontaneously in the acidotic tumor microenvironment to a cell-penetrating particle.
    [Science Advances]

    Full Article

    Tumor and Stroma COL8A1 Secretion Induces Autocrine and Paracrine Progression Signaling in Pancreatic Ductal Adenocarcinoma

    Scientists identified collagen type VIII alpha 1 chain (COL8A1) expression in seven examined PDAC cell lines by microarray analysis, western blotting, and RT‒qPCR. Higher COL8A1 expression occurred in two gemcitabine-resistant PDAC cell lines.
    [Matrix Biology]

    Abstract

    Nuclear FGFR1 Promotes Pancreatic Stellate Cell-Driven Invasion through Up-Regulation of Neuregulin 1

    By interrogating pancreatic stellate cell (PSC)-cancer cell interactions in 3D models, the authors identified nuclear FGFR1 as critical for PSC-led invasion of cancer cells.
    [Oncogene]

    Full Article
    Press Release

    RHBDL2 Promotes the Proliferation, Migration, and Invasion of Pancreatic Cancer by Stabilizing the N1ICD via the OTUD7B and Activating the Notch Signaling Pathway

    Researchers found that rhomboid-like 2 (RHBDL2) was highly expressed in human pancreatic cancer (PC) cells and tissues, and was significantly associated with distant metastasis and poor survival of patients with PC.
    [Cell Death & Disease]

    Full Article
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    REVIEWS

    Pancreas Transplantation: Current Challenges, Considerations, and Controversies

    In spite of steadily improving outcomes in each successive era coupled with expansion of recipient selection criteria to include patients with a type 2 diabetes phenotype, a decline in pancreas transplantation activity has occurred in the new millennium related to a number of factors.
    [Journal of Clinical Endocrinology & Metabolism]

    Abstract

    Inside the β cell: Molecular Stress Response Pathways in Diabetes Pathogenesis

    The authors review the critical stress response pathways that are activated in β-cells in the context of the animal models.
    [Endocrinology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Ipsen to File sNDA for Pancreatic Cancer Drug Following Positive Phase III Results

    Ipsen will seek a new approval for Onivyde (irinotecan liposome injection) as a treatment for metastatic pancreatic ductal adenocarcinoma after posting positive Phase III progression survival data.
    [BioSpace]

    Press Release

    Children to Be Screened for Diabetes Risk in UK Early Detection Trial

    Scientists are launching a trial screening programme for type 1 diabetes in the UK to detect the disease earlier and reduce the risk of life-changing complications. About 20,000 children aged between three and 13 are being invited to take part in the Early Surveillance for Autoimmune Diabetes study.
    [The Guardian]

    Press Release
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    JOB OPPORTUNITIES

    Senior Program Associate – Science in the City

    STEMCELL Technologies, Inc. – Boston, Massachusetts, United States

    PhD Studentship – Pancreatic Ductal Adenocarcinoma

    Cancer Research UK Manchester Institute – Manchester, England, United Kingdom

    Technician – Hydrogels and Beta Cells

    King’s College London – London, England, United Kingdom

    Senior Research Scientist – Pancreatic Organoid Research

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    Postdoctoral Researcher – β Cell Protection and Regeneration

    Helmholtz Munich – Neuherberg, Germany

    > See All Jobs

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