Pancreatic Cell News Volume 14.00 | Jan 03 2023

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    Jamie Kang
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    2023-01-03 | PACN 14.00


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.00 – 3 January, 2023
    TOP STORY

    Engineering Human Stem Cell-Derived Islets to Evade Immune Rejection and Promote Localized Immune Tolerance

    Scientists demonstrated that targeting human leukocyte antigens and PD-L1 alone did not sufficiently protect stem cell-derived islet cells from xenograft- or allograft-rejection.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
    Are Your Pluripotent Stem Cells What You Think They Are? Explore Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Comparative Study of Two Common In Vitro Models for the Pancreatic Islet with MIN6

    Cells from the mouse islet β cell line Min6 were constructed as scaffold-free spheroids or alginate-encapsulated dispersed cells to compare common methods of treating insulin-dependent diabetes.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    Tranilast Protects Pancreatic β-Cells from Palmitic Acid-Induced Lipotoxicity via FoxO-1 Inhibition

    Based on Forckhead box O-1 (FoxO-1)’s role in apoptotic cell death and differentiation, researchers examined the effect of tranilast on palmitic acid-induced cell damage in INS-1 cells.
    [Scientific Reports]

    Full Article

    Decorin Improves Human Pancreatic β-Cell Function and Regulates ECM Expression In Vitro

    Scientists assessed the regulatory role of the small leucine-rich proteoglycan decorin in insulin secretion in human β-cells, and its impact on pancreatic extracellular matrix protein expression in vitro.
    [Matrix Biology]

    Full Article

    Deoxyarbutin Attenuates Severe Acute Pancreatitis via the HtrA2/PGC-1α Pathway

    This in vitro study showed that deoxyarbutin (dA) significantly reduced the necrosis of primary acinar cells and reactive oxygen species accumulation, recovered mitochondrial membrane potential, and ATP exhaustion, while UCF-101 and SR-18292 eliminated the protective effect of dA.
    [Free Radical Research]

    Abstract

    Targeting T Cell Checkpoints 41BB and LAG3 and Myeloid Cell CXCR1/CXCR2 Results in Antitumor Immunity and Durable Response in Pancreatic Cancer

    Researchers systematically characterized the mechanisms underlying de novo immune checkpoint therapy resistance and identified effective therapeutic options for PDAC.
    [Nature Cancer]

    AbstractPress Release

    MYB Sustains Hypoxic Survival of Pancreatic Cancer Cells by Facilitating Metabolic Reprogramming

    Scientists identified the HuR/MYB/HIF1α axis as a critical regulator of the metabolic plasticity and hypoxic survival of pancreatic cancer cells.
    [EMBO Reports]

    AbstractGraphical Abstract

    NF-κB/RelA Controlled A20 Limits TRAIL-Induced Apoptosis in Pancreatic Cancer

    To identify differentially expressed and TNF-related apoptosis-inducing ligand (TRAIL) resistance mediating NF-κB target genes, TRAIL sensitive and resistant PDAC cell lines were analyzed by transcriptome assays. A20 was identified as an NF-κB/RelA inducible target gene.
    [Cell Death & Disease]

    Full Article

    Loss of Tumor Suppressor WWOX Accelerates Pancreatic Cancer Development through Promotion of TGFβ/BMP2 Signaling

    Investigators reported that combined conditional deletion of Wwox and activation of KRasG12D in Ptf1a-CreER-expressing mice resulted in the accelerated formation of precursor lesions and pancreatic carcinoma.
    [Cell Death & Disease]

    Full Article

    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    REVIEWS

    Stroma-Targeting Strategies in Pancreatic Cancer: A Double-Edged Sword

    The authors provide an overview of the current comprehension of the three key components of PDAC stroma and the new promising therapeutic targets for PDAC.
    [Journal Of Physiology And Biochemistry]

    Abstract

    Pancreatic KCa3.1 Channels in Health and Disease

    Investigators focus on the Ca2+-regulated K+ channel KCa3.1, encoded by the KCNN4 gene, which is present in both islets of Langerhands and exocrine pancreas.
    [Biological Chemistry]

    Abstract
    INDUSTRY AND POLICY NEWS

    TransCode Therapeutics Announces FDA Authorization to Proceed with First-In-Human Clinical Trial

    TransCode Therapeutics, Inc. announced that it has received authorization from the US FDA to proceed with its First-in-Human Phase 0 clinical trial evaluating TTX-MC138 in up to 12 cancer patients with advanced solid tumors including pancreatic cancer.
    [TransCode Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    DDR Inhibitors Summit 2023

    January 24 – 26, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – PDAC

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    Postdoctoral Researcher – Pancreatic Ductal Adenocarcinoma Pathogenesis

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    Postdoctoral Fellowship – Pancreatic Cancer Research

    Johns Hopkins University – Baltimore, Maryland, United States

    Postdoctoral Position – Nervous Organoids & Biomimetic Nanomaterials 3D Cultures

    Center for Nanomedicine and Tissue Engineering – Milan, Italy

    Postdoctoral Scientist – Cancer Therapeutics

    UTHSC-Houston – Houston, Texas, United States

    > See All Jobs

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