 | | Vol. 14.05 – 7 February, 2023 |
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| Scientists investigated the fate of A+ cells during pair-feeding by lineage-tracing, somatically ablated aldehyde dehydrogenase 1 isoform A3 (ALHD1A3) in diabetic β-cells, and used a novel selective ALDH1A3 inhibitor to treat diabetes.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators examined whether the administration of young and undamaged recombinant albumin could alleviate type 2 diabetes mellitus in mice.
[Journal of Translational Medicine] |
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| Researchers leveraged a multilayered microfluidic approach to integrate a novel oxygen gradient, 0–20%, with an enhanced hydrogel sensor to study pancreatic beta cells.
[Microsystems & Nanoengineering] |
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| To examine the role of rowth differentiation factor-15 (GDF15) in β-cell function, bioinformatics analysis, and functional experiments involving GDF15 silencing and overexpression were performed in INS-1 cells and human islets.
[Experimental Biology and Medicine] |
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| Scientists characterized the gene signature of tumor-associated nonmyelinating Schwann cells (TASc) in PDAC and indicated that the abundance of TASc was correlated with immune suppressive tumor microenvironment.
[Science Advances] |
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| To provide a deeper understanding of PDAC subtypes, the authors developed a multiplex immunofluorescence pipeline that quantified protein expression of six PDAC subtype markers and permitted spatially resolved, single-cell interrogation of pancreatic tumors.
[Cancer Research] |
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| Researchers used a genetic and a pharmacologic approach to target Arginase 1 (Arg1) in pancreatic cancer to investigate Arg1’s metabolic function.
[eLife] |
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| Investigators found that gemcitabine elicited ERK-dependent autophagy in PDAC cells, but did not stimulate ERK activity or autophagy in non-tumoral human pancreatic epithelial cells.
[Cell Death Discovery] |
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| The authors described that gemcitabiner induced a senescent-like phenotype in highly chemoresistant pancreatic cancer cells in vitro and in xenografted tumors in vivo.
[Molecular Biomedicine] |
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| Scientists conduct a systemic retrospective analysis of proteins that have been identified by comparative proteomics to be involved in the invasion and metastasis of PDAC over the past decade.
[Clinical and Translational Oncology] |
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| Dr. Elmar Wolf, Professor at the Julius-Maximilians-Universität Würzburg, has been awarded a two million euro European Research Council Consolidator Grant for his research on the development of new therapies against pancreatic cancer.
[Julius Maximilian University of Würzburg] |
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| February 22 – 23, 2023
Boston, Massachusetts, United States |
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| | Weill Cornell Graduate School of Medical Sciences – New York, New York, United States |
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| | Beckman Research Institute – Monrovia, California, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | The Johns Hopkins Wilmer Eye Institute – Baltimore, Maryland, United States |
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| | Northern California Institute for Research and Education – San Francisco, California, United States |
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