Pancreatic Cell News Volume 14.06 | Feb 14 2023

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    2023-02-14 | PACN 14.06


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.06 – 14 February, 2023
    TOP STORY

    IL-17A-Producing CD8+ T Cells Promote PDAC via Induction of Inflammatory Cancer-Associated Fibroblasts

    PDAC was characterized by an abundant desmoplastic stroma composed of cancer-associated fibroblasts and interspersed immune cells.
    [Gut]

    Full Article
    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Pancreatic Microexons Regulate Islet Function and Glucose Homeostasis

    Investigators uncovered a conserved program of alternative microexons included in mRNAs of islet cells, particularly in genes involved in vesicle transport and exocytosis.
    [Nature Metabolism]

    AbstractPress Release

    β-Cell Selective Inhibition of DNA Damage Response Signaling by Nitric Oxide Is Associated with an Attenuation in Glucose Uptake

    Researchers used multiple analytical approaches to determine changes in intermediary metabolites in β-cells and non-β-cells treated with nitric oxide or the complex I inhibitor rotenone.
    [Journal Of Biological Chemistry]

    Full Article

    A Peripherally Restricted Cannabinoid-1 Receptor Inverse Agonist Promotes Insulin Secretion and Protects from Cytokine Toxicity in Human Pancreatic Islets

    The authors showed that a peripherally restricted CB1R inverse agonist, MRI-1891, augments glucose stimulated insulin secretion in isolated human pancreatic islets and mouse islets.
    [European Journal of Pharmacology]

    Full Article

    Enhanced Endosomal Signaling and Desensitization of GLP-1R versus GIPR in Pancreatic Beta Cells

    Investigators directly compared surface expression, trafficking, and signaling characteristics of both incretin receptors in pancreatic beta cells to identify potential differences that might underlie distinct pharmacological responses associated with each receptor.
    [Endocrinology]

    Abstract

    Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and Its Tumor Microenvironment

    Researchers performed single-cell RNA sequencing on freshly collected human PDAC samples either before or after chemotherapy.
    [Nature Communications]

    Full Article

    m6A-Modified circRNA MYO1C Participates in the Tumor Immune Surveillance of Pancreatic Ductal Adenocarcinoma through m6A/PD-L1 Manner

    The authors reported that a novel N6-methyladenosine (m6A)-modified circRNA from the MYO1C gene, circMYO1C, upregulated in the PDAC.
    [Cell Death & Disease]

    Full Article

    Combination Treatment of T1-44, a PRMT5 Inhibitor with Vactosertib, an Inhibitor of TGF-β Signaling, Inhibits Invasion and Prolongs Survival in a Mouse Model of Pancreatic Tumors

    Scientists investigated whether inhibition of protein arginine methyltransferase 5 (PRMT5) activity was synergistic with blockade of TGF-β1 signaling, which plays an important role in the construction of the desmoplastic matrix in pancreatic cancer.
    [Cell Death & Disease]

    Full Article

    Repositioning Lomitapide to Block ZDHHC5-Dependant Palmitoylation on SSTR5 Leads to Anti-Proliferation Effect in Preclinical Pancreatic Cancer Models

    Researchers compared single-cell transcriptome data between pancreatic cancer tissues and normal pancreas tissues and identified that ZDHHC5 was a potential target to inhibit the proliferation of pancreatic cancer cells.
    [Cell Death Discovery]

    Full Article
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    REVIEWS

    Pancreatic Cancer: Genetic Conditions and Epigenetic Alterations

    Scientists provide a review of the genetic and epigenetic drivers of PDAC relative to recent discoveries that impact patient management.
    [Journal of Gastrointestinal Surgery]

    Abstract
    INDUSTRY AND POLICY NEWS

    $3 Million National Grant to Fund Pancreatic Cancer Study

    UC Davis Comprehensive Cancer Center partnered with TargaGenix and Northeastern University to study PDAC. The academic-industry partnership received nearly $3 million over five years thanks to National Institutes of Health funding through its R01 grant program.
    [UC Davis Health]

    Press Release
    FEATURED EVENT

    OrganoidNL Symposium 2023

    March 31, 2023
    Amsterdam, The Netherlands

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    JOB OPPORTUNITIES

    Research Assistant – Properdin in Pancreatic Cancer

    United Arab Emirates University – Al Ain, United Arab Emirates

    Postdoctoral Associate – Translational Cancer Research

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Stem Cell Biology

    Weill Cornell Graduate School of Medical Sciences – New York, New York, United States

    Staff Scientist – Genetics and Epigenetics of Gastrointestinal Cancers

    Beckman Research Institute – Monrovia, California, United States

    Senior Research Associate – Early Cancer Institute

    University of Cambridge – Cambridge, England, United Kingdom

    > See All Jobs

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