| Vol. 14.07 – 21 February, 2023 |
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| Researchers discovered that family with sequence similarity 83 member A (FAM83A) in pancreatic cancer bound directly to β-catenin and inhibited the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and degradation. [Signal Transduction and Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists characterized the molecular signature of thrombospondin-1 (TSP1), CD47, and signal regulatory protein α (SIRPα) in human islets and pancreata. [American Journal Of Physiology-Endocrinology And Metabolism] |
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| Researchers reported that GIV was a signaling mediator coordinating glucose-stimulated Nephrin phosphorylation and endocytosis with insulin secretion. [Journal of Biological Chemistry] |
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| PDZ binding kinase was significantly upregulated in pancreatic neuroendocrine neoplasm tissues compared with paracancerous tissues. [Molecular Carcinogenesis] |
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| The authors differentiated human pluripotent stem cells (hPSC) toward pancreatic progenitor (PP) lineage and repopulated decellularized organ scaffolds with these hPSC-PP cells. [Biomedical Materials] |
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| A novel microfluidic encapsulated and integrated primary pancreatic cancer cells platform was proposed for biomimetic tumor 3D cultivation and clinical drug evaluation. [Advanced Science] |
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| Investigators found for the first time that KIF15 promoted the glycolytic capacity of pancreatic cancer (PC) cells and PC tumor growth. Moreover, the expression of KIF15 was negatively correlated with the prognosis of PC patients. [Cell Death & Disease] |
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| Researchers showed that suppression of fatty acid oxidation by hypoxia induced autophagy in human PDAC cells that was required for their growth and survival. [Cancer Gene Therapy] |
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| Investigators unveiled the function of circ_0128846 in pancreatic cancer. The expressions of circ_0128846, miR-1270, and NR3C1 mRNA were measured via RT-qPCR. [Scientific Reports] |
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| The authors describe the major signaling pathways and molecular mechanisms involved in PDAC initiation and progression in addition to the immunosuppressive tumor microenvironment of PDAC. [MedComm] |
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| Akamis Bio announced an expansion of its ongoing partnership with the Parker Institute for Cancer Immunotherapy to include a clinical collaboration with the Cancer Research Institute that will focus on advancing novel treatments for pancreatic cancer. [Akamis Bio] |
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| March 19 – 23, 2023 Banff, Alberta, Canada |
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| The Henry Ford Health System – Detroit, Michigan, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| University of Gothenburg – Gothenburg, Sweden |
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| United Arab Emirates University – Al Ain, United Arab Emirates |
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| Baylor College of Medicine – Houston, Texas, United States |
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