Pancreatic Cell News Volume 14.07 | Feb 21 2023

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    2023-02-21 | PACN 14.07


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.07 – 21 February, 2023
    TOP STORY

    B-Lymphoid Tyrosine Kinase-Mediated FAM83A Phosphorylation Elevates Pancreatic Tumorigenesis through Interacting with β-Catenin

    Researchers discovered that family with sequence similarity 83 member A (FAM83A) in pancreatic cancer bound directly to β-catenin and inhibited the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and degradation.
    [Signal Transduction and Targeted Therapy]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Thrombospondin-1, CD47, and SIRPα Display Cell-Specific Molecular Signatures in Human Islets and Pancreata

    Scientists characterized the molecular signature of thrombospondin-1 (TSP1), CD47, and signal regulatory protein α (SIRPα) in human islets and pancreata.
    [American Journal Of Physiology-Endocrinology And Metabolism]

    Abstract

    The Signaling Protein GIV/Girdin Mediates the Nephrin-Dependent Insulin Secretion of Pancreatic Islet β Cells in Response to High Glucose

    Researchers reported that GIV was a signaling mediator coordinating glucose-stimulated Nephrin phosphorylation and endocytosis with insulin secretion.
    [Journal of Biological Chemistry]

    Full Article

    PDZ-Binding Kinase Aggravates Pancreatic Neuroendocrine Neoplasm Progression by Activating the AKT/mTOR Pathway

    PDZ binding kinase was significantly upregulated in pancreatic neuroendocrine neoplasm tissues compared with paracancerous tissues.
    [Molecular Carcinogenesis]

    Abstract

    Repopulation of Decellularized Organ Scaffolds with Human Pluripotent Stem Cell-Derived Pancreatic Progenitor Cells

    The authors differentiated human pluripotent stem cells (hPSC) toward pancreatic progenitor (PP) lineage and repopulated decellularized organ scaffolds with these hPSC-PP cells.
    [Biomedical Materials]

    Full Article

    Primary Human Pancreatic Cancer Cells Cultivation in Microfluidic Hydrogel Microcapsules for Drug Evaluation

    A novel microfluidic encapsulated and integrated primary pancreatic cancer cells platform was proposed for biomimetic tumor 3D cultivation and clinical drug evaluation.
    [Advanced Science]

    Full Article

    KIF15 Is Essential for USP10-Mediated PGK1 Deubiquitination during the Glycolysis of Pancreatic Cancer

    Investigators found for the first time that KIF15 promoted the glycolytic capacity of pancreatic cancer (PC) cells and PC tumor growth. Moreover, the expression of KIF15 was negatively correlated with the prognosis of PC patients.
    [Cell Death & Disease]

    Full Article

    Suppression of Fatty Acid Oxidation Supports Pancreatic Cancer Growth and Survival under Hypoxic Conditions through Autophagy Induction

    Researchers showed that suppression of fatty acid oxidation by hypoxia induced autophagy in human PDAC cells that was required for their growth and survival.
    [Cancer Gene Therapy]

    Abstract

    Hsa_circ_0128846 Knockdown Attenuates the Progression of Pancreatic Cancer by Targeting miR-1270/NR3C1 Axis

    Investigators unveiled the function of circ_0128846 in pancreatic cancer. The expressions of circ_0128846, miR-1270, and NR3C1 mRNA were measured via RT-qPCR.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Targeted Therapy for Pancreatic Ductal Adenocarcinoma: Mechanisms and Clinical Study

    The authors describe the major signaling pathways and molecular mechanisms involved in PDAC initiation and progression in addition to the immunosuppressive tumor microenvironment of PDAC.
    [MedComm]

    Full Article
    INDUSTRY AND POLICY NEWS

    Akamis Bio, Parker Institute for Cancer Immunotherapy and Cancer Research Institute Announce Expanded Partnership to Advance Novel Treatments for Pancreatic Cancer

    Akamis Bio announced an expansion of its ongoing partnership with the Parker Institute for Cancer Immunotherapy to include a clinical collaboration with the Cancer Research Institute that will focus on advancing novel treatments for pancreatic cancer.
    [Akamis Bio]

    Press Release
    FEATURED EVENT

    Fibrosis Pathogenesis and Resolution: From Mechanisms to Therapies

    March 19 – 23, 2023
    Banff, Alberta, Canada

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Cancer Biology

    The Henry Ford Health System – Detroit, Michigan, United States

    Postdoctoral Fellow – Cardiovascular Metabolism

    The University of British Columbia – Vancouver, British Columbia, Canada

    PhD Position – Spatial Transcriptomics in Metabolic & Cardiovascular Disease

    University of Gothenburg – Gothenburg, Sweden

    Research Assistant – Properdin in Pancreatic Cancer

    United Arab Emirates University – Al Ain, United Arab Emirates

    Postdoctoral Associate – Translational Cancer Research

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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