 | | Vol. 14.09 – 7 March, 2023 |
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| Investigators explored an approach in which allogeneic islets were transplanted onto the omentum, which was bioengineered with a plasma-thrombin biodegradable matrix in three diabetic non-human primates.
[Cell Reports Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Sulfated fuco-manno-glucuronogalactan attenuated senescence and improved beta cell function via PI3K/Akt/FoxO1 signaling pathway.
[International Journal of Biological Macromolecules] |
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| Using micro-manipulation and three-dimensional colony assays scientists identified cells within the adult human exocrine pancreas that resembled progenitor cells.
[Stem Cell Reports] |
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| The authors explored the mechanism through which taurine reduced glycolipid toxicity. INS-1 islet β-cell lines were cultured with a high concentration of fat and glucose.
[Food and Chemical Toxicology] |
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| Investigators indicated that ribonucleotide reductase large subunit M1 (RRM1) expression was critical for the migratory and invasive potential of pancreatic cancer cells.
[International Journal Of Oncology] |
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| Researchers explored the predictive ability of T cell marker genes score to predict their overall survival and treatment response to immune checkpoint blockade by integrating single-cell RNA sequencing and bulk RNA-seq data, where multi-omics data of PDAC were applied.
[Scientific Reports] |
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| The authors confirmed that serine/threonine kinase 3 (STK3) has an impact on the growth, apoptosis, and metastasis of pancreatic cancer cells and investigated the related molecular mechanisms.
[Cellular Signalling] |
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| Investigators found that PDAC-derived collagen type XI alpha 1 (COL11A1) promoted the conversion of normal fibroblasts to cancer-associated fibroblast-like cells. It included morphological and corresponding molecular marker changes.
[Cell Biology International] |
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| The effects of joint radiotherapy/hyperthermia on optimized chick embryo chorioallantoic membrane pancreatic tumor models were investigated.
[Advanced Biology] |
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| The authors discuss the current understanding of PDAC metabolism by specifically exploring the metabolic dependencies of cancer stem cells (CSCs). They also review the current knowledge of targeting these metabolic factors that regulate CSC maintenance and PDAC progression.
[Stem Cells] |
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| Scientists focus on signaling pathways that regulate adaptive β-cell proliferation for the treatment of diabetes considering the abovementioned issues.
[Journal of Diabetes Investigation] |
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| Panbela Therapeutics, Inc. announced its first patient enrolled in South Korea for its ASPIRE global clinical trial in the first-line treatment of metastatic pancreatic cancer.
[Panbela Therapeutics, Inc.] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | Moffitt Cancer Center – Tampa, Florida, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Missouri – Columbia, Missouri, United States |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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