 | | Vol. 14.12 – 29 March, 2023 |
| |
|
|
| Scientists used genetic and pharmacological approaches in human and mouse in vitro and in vivo models to show that PDAC has a distinct dependence on de novo ornithine synthesis from glutamine.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Investigators identified two major subtypes of pancreatic β cells based on histone mark heterogeneity, βHI and βLO. βHI cells had increased mitochondrial mass, activity, and insulin secretion in vivo and ex vivo.
[Cell Metabolism] |
|
|
|
| The authors explored protective actions of kaempferol in interleukin-1β-treated RINm5F β-cells. They found that kaempferol significantly inhibited nitric oxide generation, inducible nitric oxide synthase (iNOS) protein, and iNOS mRNA levels.
[Heliyon] |
|
|
|
| Pre-treatment with interleukin (IL)-6 sensitized INS-1E cells to cytokine-induced cell death, increasing cytokine-induced inducible nitric oxide synthase and Caspase-3 expression.
[BMC Molecular and Cell Biology] |
|
|
|
| Scientists presented an optimized pancreatic β cell differentiation procedure using human pluripotent stem cells. The application of methionine and zinc deprivation facilitated the generation of functional pancreatic β cells.
[STAR Protocols] |
| |
|
|
| N6-methyladenosine methyltransferase METTL3 was upregulated in PDAC tissues with gemcitabine resistance, and its knockdown sensitized pancreatic cancer cells to chemotherapy.
[Cell Death & Disease] |
|
|
|
| The authors showed that high NUAK1 expression was associated with reduced overall survival in PDAC and that inhibition or depletion of NUAK1 suppressed the growth of PDAC cells in culture.
[Molecular Oncology] |
|
|
|
| Scientists showed that ovarian cancer cell SKOV3 could significantly inhibit the proliferation of pancreatic cancer cell SW1990 when they were co-cultured.
[Aging] |
|
|
|
| Researchers found that down-regulation of lncRNA CASC9 in pancreatic cancer cells could significantly suppress the cell aggressiveness both in vitro and in vivo.
[Environmental Toxicology] |
|
|
|
|
| Scientists outline single-cell analyses in PDAC, discuss their implications on our understanding of the disease and present future perspectives of multimodal approaches.
[Nature Cancer] |
|
|
|
| The authors describe novel model systems and thoroughly examine microfluidic chips, synthetic matrices, multicellular systems, bioprinting, and stem cell-derived pancreatic organoid systems.
[Expert Opinion on Drug Discovery] |
|
|
|
|
| Diane Saunders, PhD, research assistant professor in the Division of Diabetes, Endocrinology & Metabolism in the Department of Medicine, has been selected as a 2023 recipient of an Innovation Award by the Network of Pancreatic Donors with Diabetes.
[Vanderbilt University Medical Center] |
|
|
|
| Vertex Pharmaceuticals Incorporated and CRISPR Therapeutics announced that they have entered into a new non-exclusive licensing agreement for the use of CRISPR Therapeutics’ gene editing technology to accelerate the development of Vertex’s hypoimmune cell therapies for type 1 diabetes.
[Vertex Pharmaceuticals Incorporated] |
|
|
|
|
| July 24 – 28, 2023
Boston, Massachusetts, United States |
|
|
|
|
|
| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
|
|
|
| | University of California San Francisco – San Francisco, California, United States |
|
|
|
| | Oslo University Hospital – Oslo, Norway |
|
|
|
| | Columbia University – New York, New York, United States |
|
|
|
| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
