 | | Vol. 14.13 – 4 April, 2023 |
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| Loss of PDAC cell-intrinsic focal adhesion kinase (FAK) signaling promoted expression of the immunoproteasome and Major Histocompatibility Complex class-I, resulting in increased antigen diversity and antigen presentation by FAK-/- PDAC cells.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators determined whether nuclear factor-Y-mediated apoptosis made an essential contribution to β cell compensation upon metabolic stress.
[Chinese Medical Journal] |
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| The glucocorticoid-mediated transcriptomic changes in human pancreatic islets and the human insulin-secreting EndoC-βH1 cells were investigated to uncover genes involved in β cell steroid stress-response processes.
[iScience] |
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| Scientists investigated the role of a cyclin-dependent kinase 5 (CDK5) inhibitor, TFP5, in islet β-cell damage under diabetic conditions by regulating the expression of CDK5 in vitro and in vivo.
[Chemical Biology & Drug Design] |
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| The authors demonstrated a novel mode of acquired chemoresistance in PDAC and identified the miR-3173–5p/ACSL4 pathway.
[Drug Resistance Updates] |
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| Researchers showed that cerium oxide CeO2 nanoparticles exhibited an remarkable elevated level of reactive oxygen species production in tumor cells, as compared to healthy cells.
[Journal of Nanobiotechnology] |
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| The biological functions of ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) in PDAC cell growth, migration, and invasion were determined using gain- and loss-of-function assays with both in vitro and in vivo animal models.
[Genes & Diseases] |
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| circACTR2 was notably down-regulated in a panel of gemcitabine-resistant pancreatic cancer (PC) cell lines, and negatively associated with aggressive phenotype and poor prognosis of PC.
[Biology Direct] |
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| ASBEL suppressed apoptosis and the expression of BTG3, enhanced proliferation, and promoted migration and invasion in pancreatic cancer cells.
[Current Therapeutic Research] |
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| Scientists provide a comprehensive and critical analysis of the immunometabolic mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis and dissect how metabolic disorders impair anticancer immunity.
[Signal Transduction and Targeted Therapy] |
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| Alpha Tau Medical Ltd. announced that its first patient with advanced inoperable pancreatic cancer has been treated in a feasibility and safety study of Alpha DaRT at the Jewish General Hospital in Montreal, Canada, an affiliated teaching hospital of McGill University, Faculty of Medicine.
[Alpha Tau Medical Ltd.] |
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| April 30 – May 5, 2023
Barga, Italy |
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| | CRUK Beatson Institute – Glasgow, Scotland, United Kingdom |
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| | City of Hope – Monrovia, California, United States |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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| | Oslo University Hospital – Oslo, Norway |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
