Pancreatic Cell News Volume 14.14 | Apr 11 2023

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    2023-04-11 | PACN 14.14


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.14 – 11 April, 2023
    TOP STORY

    USP9X Mediates an Acute Adaptive Response to MAPK Suppression in Pancreatic Cancer but Creates Multiple Actionable Therapeutic Vulnerabilities

    Researchers demonstrated that USP9X regulated a critical mechanism of resistance in PDAC and revealed an unexpected mechanism of Mcl-1 regulation in response to RAS pathway suppression.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Understanding Cell Fate Acquisition in Stem-Cell-Derived Pancreatic Islets Using Single-Cell Multiome-Inferred Regulomes

    Investigators acquired single-cell transcriptomes and accessible chromatin profiles during in vitro islet differentiation and pancreas from childhood and adult donors for comparison.
    [Developmental Cell]

    AbstractGraphical Abstract

    Extrahepatic Transplantation of 3D Cultured Stem Cell-Derived Islet Organoids on Microporous Scaffolds

    The authors investigated 3D culture of human stem cell-derived islet organoids, with 3D culture initiated at the pancreatic progenitor, endocrine progenitor, or immature β-cell stage.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Control of Human Pancreatic Beta Cell Kinome by GLP-1R Biased Agonism

    Researchers determined the kinase activity profiles of human pancreatic beta cells downstream of GLP-1R balanced versus biased agonist stimulations.
    [Diabetes Obesity & Metabolism]

    Abstract

    NR3C1/Glucocorticoid Receptor Activation Promotes Pancreatic β Cell Autophagy Overload in Response to Glucolipotoxicity

    Scientists proved that deleterious hyperactive autophagy happened only upon NR3C1 activation in β cells under glucolipotoxic conditions, which eventually promoted diabetes.
    [3D Printing And Additive Manufacturing]

    Abstract

    An ERK1/2-Driven RNA-Binding Switch in Nucleolin Drives Ribosome Biogenesis and Pancreatic Tumorigenesis Downstream of RAS Oncogene

    Using quantitative RNA interactome capture analysis, the authors revealed that oncogenic RAS signaling reshaped the RNA-bound proteomic landscape of pancreatic cancer cells.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Adjustable Extracellular Matrix Rigidity Tumor Model for Studying Stiffness Dependent Pancreatic Ductal Adenocarcinomas Progression and Tumor Immunosuppression

    A gelatin methacryloyl (GelMA)-based hydrogel was designed for in vitro and in vivo PDAC experiments.The GelMA-based in vitro 3D culture method could effectively form a gradient and stable extracellular matrix stiffness.
    [Bioengineering & Translational Medicine]

    Full Article

    PSMD12 Interacts with CDKN3 and Facilitates Pancreatic Cancer Progression

    Bioinformatics analysis showed that PSMD12 was highly expressed in pancreatic cancer (PC) patients and was associated with shorter overall survival. PSMD12 was also shown to be highly expressed in PC tissues and cell lines.
    [Cancer Gene Therapy]

    Abstract

    Azeliragon Inhibits PAK1 and Enhances the Therapeutic Efficacy of AKT Inhibitors in Pancreatic Cancer

    Cell experiments revealed that azeliragon abolished p21-activated kinase 1 (PAK1) activation and promoted apoptosis in pancreatic cancer cells.
    [European Journal of Pharmacology]

    Abstract
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    REVIEWS

    Novel Strategy for Oncogenic Alteration-Induced Lipid Metabolism Reprogramming in Pancreatic Cancer

    Scientists focus on the mechanisms regulating lipid metabolism reprogramming in pancreatic cancer cells to provide new therapeutic targets and aid the development of new therapeutic strategies for pancreatic cancer.
    [Acta Biochimica et Biophysica Sinica]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    UTEP to Investigate Pancreatic Cancer Risk Factors with $1M NIH Grant

    The University of Texas at El Paso (UTEP) announced that it will undertake potentially transformative research on how specific risk factors promote pancreatic cancer development with support from a $1 million grant from the National Institutes of Health’s (NIH) National Cancer Institute.
    [The University of Texas at El Paso]

    Press Release
    FEATURED EVENT

    Type 2 Diabetes: Understanding Its Early Drivers and the Road to Therapeutics

    May 1 – 4, 2023
    Palm Springs, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Neuroendocrine System

    Howard Hughes Medical Institute – Ashburn, Virginia, United States

    Research Associate – Molecular Diagnostics and Experimental Therapeutics

    City of Hope – Monrovia, California, United States

    Postdoctoral Research Scientist – Pancreatic Cancer Microenvironment

    CRUK Beatson Institute – Glasgow, Scotland, United Kingdom

    Postdoctoral Fellow – Prostate Cancer and Pancreas Cancer Research

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Faculty Position – Diabetes Center

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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