 | | Vol. 14.15 – 18 April, 2023 |
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| Researchers reported the editing of primary human islet cells to the hypoimmune HLA class I– and class II–negative and CD47-overexpressing (HIP) phenotype, and their reaggregation into human HIP pseudoislets.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that diluted plasma from obese human donors acutely impaired β-cell integrity and insulin secretion relative to plasma from lean subjects.
[Aging Cell] |
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| To determine the collective roles of Prader-Willi syndrome genes in β-cell biology, researchers used genome-editing to generate isogenic, clonal INS-1 insulinoma lines having 3.16 Mb deletions of the silent, maternal- and active, paternal-allele.
[PLOS Genetics] |
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| Using mass spectrometry-based phosphoproteomics to search for downstream effectors of glucose-dependent signal transduction in INS-1E insulinoma cells, scientists identified the outer mitochondrial membrane protein SLC25A46.
[Journal of Cell Science] |
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| The authors evaluated the therapeutic utility of CXCR2/1 targeting using an small molecule antagonist, SCH-479833, in different pancreatic cancer preclinical murine models.
[Cancer Letters] |
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| Investigators explored the combined antitumor activity of fibroblast activation protein (FAP)-targeted and claudin 18.2-targeted CAR-T cells against PDAC.
[Journal of Translational Medicine] |
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| Scientists discovered that circ-STK39 expression increased in pancreatic cancer (PC) tissues and cells, suggesting that circ-STK39 may have a role in PC progression.
[Apoptosis] |
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| Researchers explored the association between nuclear receptor-binding SET domain 3 (NSD3) expression and described features of the tumor microenvironment in PDAC, a severe type of pancreatic cancer.
[Cancer Medicine] |
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| Wound healing, transwell, and EdU assays were performed to investigate the effect of circPTPRA on the migration, invasion, and proliferation of PDAC cells in vitro.
[Cancer Medicine] |
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| The authors highlight the foundational studies that have driven our understanding of the processes affecting PDAC pathogenesis and progression.
[Cell] |
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| A perplexing feature of type 1 diabetes is that the immune system destroys pancreatic β-cells but not neighboring α-cells, even though both β-cells and α-cells are dysfunctional.
[Nature Reviews Endocrinology] |
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| Researchers at the University of Alabama at Birmingham (UAB) have received more than $3.7 million from the National Institutes of Health to study the increasing prevalence of diabetes in youth as part of a nationwide consortium.
[The University of Alabama at Birmingham] |
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| The biologist and medical researcher Matthias Hebrok is being awarded a Bavarian Distinguished Professorship. Hebrok works with pancreatic organoids in order to investigate diagnostic and therapeutic possibilities in pancreatic cancer and to enable cell replacement therapies for diabetes patients.
[Technical University of Munich] |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Howard Hughes Medical Institute – Ashburn, Virginia, United States |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | City of Hope – Monrovia, California, United States |
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| | CRUK Beatson Institute – Glasgow, Scotland, United Kingdom |
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