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| The bispecific PD1-IL2v is a PD-1-targeted interleukin-2 variant (IL-2v) immunocytokine with engineered IL-2 cis targeted to PD-1 and abolished IL-2Rα binding, which enhanced tumor-antigen-specific T cell activation while reducing regulatory T cell suppression.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Single-cell RNA sequencing analysis showed that the top four differentially and selectively expressed genes in human islet endocrine cells in vitro and in vivo were not the canonical genes but a new set of non-canonical gene markers.
[Genome Medicine] |
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| The authors explored the effect of cordycepin, a natural adenosine isolated from Cordyceps militaris, on high glucose/lipid-induced glucotoxicity and lipotoxicity in INS-1 cells.
[Biomedicine & Pharmacotherapy] |
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| Inhibition of USP1 either by genetic intervention or small molecule inhibitor ML323 restored epithelial phenotype of β-cells, but not with inhibition of other deubiquitinases.
[iScience] |
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| By gaining the targeting ability of stem cells against pancreatic tumor cells, stem cell membranes encapsulated nano polylactide-co-glycolide loaded with doxorubicin to target and reduce deep pancreatic tumor tissues.
[Advanced Materials] |
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| Researchers showed that a cellular subpopulation with a partial epithelial-mesenchymal transition-like signature marked by high expression of receptor tyrosine kinase-like orphan receptor 1 (ROR1) was the origin of heterogeneous tumor cells in PDAC.
[Embo Journal] |
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| Scientists explored the mechanism of chemotherapy-induced pyroptosis and elucidated the role of pyroptosis in mediating PDAC progression and chemoresistance.
[Cancer Letters] |
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| Researchers demonstrated that retinoic acid receptor β transcriptionally repressed myosin light chain 2 expression in pancreatic cancer cells.
[Oncogenesis] |
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| The authors observed that both cysteamine and exosomes secreted by VNN1‑overexpressing pancreatic cancer cells aggravated the dysfunction of mouse primary islets.
[Oncology Reports] |
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| Investigators discuss the molecular and immunological mechanisms by which aberrant tyrosine kinase c-SRC (SRC) activity promotes PDAC tumorigenesis.
[Oncogene] |
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| Long-awaited decision comes more than a year after Francis Collins resigned as director of the largest public funder of biomedical research in the world.
[Nature] |
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| May 28 – 31, 2023
Killarney, Ireland |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | UNMC Pancreatic Cancer Center of Excellence – Omaha, Nebraska, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | Howard Hughes Medical Institute – Ashburn, Virginia, United States |
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