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| The authors found that basal PDACs were uniquely sensitive to transcriptional inhibition by targeting cyclin-dependent kinase 7 (CDK7) and CDK9, and this sensitivity was recapitulated in the basal subtype of breast cancer.
[Science Translational Medicine] |
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|
 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators screened for binding partners of neurogenin 3 (NGN3) and identified the deubiquitylating enzyme ubiquitin-specific peptidase 7 (USP7) as a key regulator of NGN3 stability.
[Nature Communications] |
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| Scientists demonstrated in both mice models and human cohorts that pancreatitis was associated with an increase in estrogen-related receptor γ (ERRγ) gene expression via activation of STAT3.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers described a 96-well-based static suspension culture method for differentiation of pancreatic progenitors into human pluripotent stem cell-islets.
[Cell Reports Methods] |
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| To investigate the roles of glutaminase 2 (GLS2) in pancreatic β-cells in vivo, the authors generated β-cell-specific Gls2 conditional knockout mice, examined their glucose homeostasis, and validated the findings using a human islet single-cell analysis database.
[Scientific Reports] |
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| Researchers devised a comprehensive azidonorleucine labeling, click chemistry enrichment, and mass spectrometry-based proteomics and secretomics strategy to dissect aberrant signals in PDAC.
[Nature Communications] |
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| Scientists found that prognostic microfibril associated protein 5 (MFAP5) was involved in activation of cancer-associated fibroblasts (CAFs). CAFs derived from both human and mouse PDAC tumors were isolated and cultured.
[Oncogene] |
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| Using in vitro and in vivo models, the authors showed that KMT2D silencing was mediated by transforming growth factor-β (TGF-β) upregulation of microRNA-147b.
[International Journal of Cancer] |
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| Researchers used 5-ethynyl-2′-deoxyuridine, cell counting kit-8, flow cytometry, and western blot experiments to confirm that agrimoniin could significantly inhibit the proliferation of pancreatic cancer cell PANC-1 by inducing apoptosis and cell cycle arrest.
[Phytotherapy Research] |
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| Scientists highlight the most recent advances in the generation and characterization of highly functional stem cell islets as well as strategies to ensure graft viability and safety after transplantation.
[Cell Stem Cell] |
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| Radiopharm Theranostics announced that the US FDA has granted Orphan Drug Designation to Ga68-Trivehexin, RAD 301, radiopharmaceutical technology for imaging of patients with PDAC.
[Radiopharm Theranostics] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | University of Geneva – Geneva, Switzerland |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | The University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | UNMC Pancreatic Cancer Center of Excellence – Omaha, Nebraska, United States |
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