 | | Vol. 14.18 – 16 May, 2023 |
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| To investigate the origins and impact of epigenetic plasticity during early neoplasia, the authors performed single-cell analyses on normal, inflamed, premalignant, and malignant tissues in autochthonous models of pancreatic cancer.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that mouse β cells lacking γ-carboxylation failed to adapt their insulin secretion in the context of age-related insulin resistance or diet-induced β cell stress.
[Cell Reports] |
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| Investigators reported that zinc finger homeobox 2 (Zhx2) orchestrated β cell mass and function by regulating paired box protein pax-6 (Pax6).
[iScience] |
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| Researchers elucidated the β-cell protective effect of VGF nerve growth factor inducible (VGF) on a streptozotocin-induced diabetic model using VGF-overexpressing mice and also examined the therapeutic effect by a small molecule, SUN N8075, which is an inducer of VGF.
[Journal of Endocrinology] |
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| Scientists dentified SUMO-specific protease 3 (SENP3) as a potential suppressor of PDAC progression through an in vivo metastatic model. Further studies revealed that SENP3 inhibited PDAC invasion in a SUMO system dependent fashion.
[Cell Death & Differentiation] |
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| Investigators reported that ezrin expression in PDAC cell-derived small extracellular vesicles could activate fibroblasts, resulting in increased migration ability and high expression of α-SMA, PDGFRB, and high production of extracellular matrix in fibroblasts.
[Molecular Oncology] |
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| The authors demonstrated that METTL3, the key regulator of N6-methyladenosine modification, was downregulated in PDAC, and negatively correlated with PDAC malignant features.
[Cellular Oncology] |
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| Natural killer (NK) cells expanded in this method showed greater cytotoxicity than resting NK cells, when co-cultured with pancreatic cancer cell lines.
[Scientific Reports] |
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| Scientists explored the possible role of SPOCK2 in the pathogenesis of PDAC and evaluated SPOCK2 in seven PDAC cell lines and one normal pancreatic cell line using quantitative RT-PCR.
[Journal of Cancer Research and Clinical Oncology] |
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| Petite integration factor 1 (PIF1) expression was upregulated in pancreatic cancer tissues and cells. Knockdown of PIF1 exhibited a repressive impact on the viability of AsPC-1 and PANC-1 cells.
[Journal of Applied Toxicology] |
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Scientists summarize current knowledge of pancreatic cancer stem cells (PCSCs) from an oncology perspective, discuss developments in the field of PCSCs and, more importantly, focus on elucidating that PCSCs exist as a plastic state.
[Journal of Experimental & Clinical Cancer Research] |
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| The FDA has granted an orphan drug designation for PYX-201 to continue its development as a treatment for patients with pancreatic cancer.
[Pyxis Oncology, Inc. (Targeted Oncology)] |
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| June 3 – 7, 2023
San Diego, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Geneva – Geneva, Switzerland |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | Weill Cornell Medical College – New York, New York, United States |
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| | UNMC Pancreatic Cancer Center of Excellence – Omaha, Nebraska, United States |
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