 | | Vol. 14.19 – 23 May, 2023 |
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| Researchers identified uridine as a fuel for pancreatic ductal adenocarcinoma in glucose-deprived conditions by assessing how more than 175 metabolites impacted metabolic activity in 21 pancreatic cell lines under nutrient restriction.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified androgen receptor genomic and non-genomic actions that enhance glucagon-like peptide-1-stimulated insulin exocytosis in male β cells.
[Cell Reports] |
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| Investigators explored the cell autonomous role of the cell cycle regulator and transcription factor E2F1 in the maintenance of β-cell identity, insulin secretion, and glucose homeostasis.
[Diabetes] |
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| Seven previously undescribed diterpenoids, tinocrisposides A–D and borapetic acids A, B, and C, together with 16 known compounds, were isolated from the stem of Tinospora crispa. The β-cell protective effect of the compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment.
[Journal Of Natural Products] |
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| | Scientists showed that leucettines, known to be dual-specific tyrosine-(Y) phosphorylation regulated kinase (DYRK1A) inhibitors, could improve glucose-stimulated insulin secretion in rodent β-cells and isolated islets, as well as in human induced pluripotent stem cell-derived β-cells islets.
[PLOS One] |
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| The authors provided an analysis that enabled the derivation of gene lists and activity for identifying each human pluripotent stem cell-derived islets-islet cell type compared with primary islets.
[Nature Cell Biology] |
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| Investigators examined the role that methyltransferase-like 3 (METTL3) played in pancreatic cancer cell proliferation and stemness. They discovered that in pancreatic cancer cells, METTL3-mediated N6-methyladenosine (m6A) alterations regulated ID2 as a downstream target.
[Cancer Letters] |
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| Researchers found protein tyrosine phosphatase nonreceptor type 2 (PTPN2) expression was downregulated in PDAC tissues, and decreased PTPN2 expression was associated with unfavorable prognosis.
[Molecular Carcinogenesis] |
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| The regulation of enhancer of zeste homolog 2 (EZH2) gene on proliferation and migration of normal pancreatic cell and pancreatic cancer cell were determined by MTS, colony forming, Ki-67 antibody, scratch and, Transwell assays.
[Hereditas] |
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| The authors review key knowledge related to the prediction and prevention of type 1 diabetes in youth, with a focus on both pharmacological and non-pharmacological prevention.
[Pharmacological Research] |
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| The funding is part of an $8.92 million investment to support 24 research projects and clinical trials nationwide, with 23 partner organizations committing $9.44 million. The UBC projects will advance research in various areas including muscular dystrophy, diabetes, protein-based therapies, and heart health.
[UBC Faculty of Medicine] |
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| June 4 – 7, 2023
Heidelberg, Germany |
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| | University of Twente – Enschede, Netherlands |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Geneva – Geneva, Switzerland |
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| | Weill Cornell Medical College – New York, New York, United States |
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