 | | Vol. 14.20 – 30 May, 2023 |
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| Investigators demonstrated that 3-Hydroxybutyrate reduced fasting blood glucose levels, improved glucose tolerance, and ameliorated insulin resistance in type 2 diabetic mice through hydroxycarboxylic acid receptor 2.
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated the role of the Fufang-Zhenzhu-Tiaozhi capsule, a traditional Chinese medicine, in promoting β-cell regeneration in T1DM mice, and further explored its mechanism.
[Journal Of Ethnopharmacology] |
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| Researchers elucidated the molecular mechanisms underlying pancreatic endoderm differentiation by searching for factors that regulate a crucial pancreatic endoderm marker gene, NKX6.1.
[Scientific Reports] |
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| Investigators showed that intravenous injection of human umbilical cord-MSCs engrafted into the injured pancreas and promoted pancreatic β-cell function in a mouse model of type 1 diabetes mellitus.
[Journal Of Molecular Cell Biology] |
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| Scientists conducted an in vitro study investigating the effects of silibinin on palmitic acid and high glucose-induced cell loss and ferroptosis of rat insulinoma INS-1 cells.
[Archives Of Biochemistry And Biophysics] |
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| Investigators developed a Clostridium perfringens enterotoxin 17-containing liposome that targeted pancreatic cancers through binding to exposed claudin-4.
[Biomaterials Research] |
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| Scientists found that pleckstrin homology and RhoGEF domain containing G5 (PLEKHG5), a RhoGEF, was highly upregulated in sorafenib-resistant cells. PLEKHG5 overexpression activated Rac1/AKT/NF-κB signaling and reduced sensitivity to sorafenib in HCC cells.
[Cell Death Discovery] |
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| Investigators demonstrated that Pulsatilla Decoction markedly inhibited PAC cell proliferation and triggered their apoptosis.
[Chinese Medicine] |
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| Researchers investigated whether lysophosphatidic acid (LPA) receptor-mediated signaling regulated cellular functions by the tumor microenvironment of pancreatic cancer PANC-1 cells.
[Journal Of Bioenergetics And Biomembranes] |
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| The authors provide an overview of PDAC, pancreatic stellate cells and their interactions with cancer cells, as well as the currently known role of extracellular vesicles derived from pancreatic stellate cells in PDAC progression.
[Seminars In Cancer Biology] |
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| Investigators look into the interrelationship between COVID-19 and diabetes mellitus with the aim to provide mechanistic insights into the process by which SARS-CoV-2 infects the pancreas and mediates dysfunction and death of endocrine islets.
[Advanced Biology] |
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| Xilio Therapeutics, Inc. announced preliminary data from its Phase I clinical trial evaluating XTX101, an investigational tumor-activated, Fc-enhanced anti-CTLA-4, in patients with advanced solid tumors.
[Xilio Therapeutics, Inc.] |
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| June 15 – 18, 2023
Chicago, Illinois, United States |
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| | City of Hope – Duarte, California, United States |
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| | University of Twente – Enschede, Netherlands |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University of Geneva – Geneva, Switzerland |
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