 | | Vol. 14.22 – 13 June, 2023 |
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| Scientists demonstrated the moonlighting functions of CD73 in immunosuppression in pancreatic cancer, an ideal model characterized by complex crosstalk among cancer metabolism, immune microenvironment, and immunotherapeutic resistance.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated the survival mechanism of the growth hormone-releasing hormone (GHRH) agonist MR-409 on human and rodent β-cells and in preclinical models of type 1 diabetes.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The reduction of ZNF148 in human islets, and its deletion in stem cell–derived β cells, enhanced insulin secretion. These findings point to ZNF148 as a regulator of annexin-S100 complexes in human β cells and suggest that its suppression may provide a novel therapeutic strategy to enhance insulin secretion.
[JCI Insight] |
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| Scientists generated a beta-cells-specific BAG3 knockout mouse model. Glucose and insulin tolerance tests, proteomics, metabolomics, and immunohistochemical analysis were used to investigate the role of BAG3 in regulating insulin secretion and the effects of chronic exposure to excessive insulin release in vivo.
[Molecular Metabolism] |
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| Investigators studied the expression profiles of ATPase H+ transporting accessory protein 2 (ATP6AP2) in pancreatic endocrine cells, and found that ATP6AP2 was robustly expressed in pancreatic insulinoma cells as well as in normal β cells.
[Scientific Reports] |
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| Scientists measured the impact of ANGPTL4 overexpression in a common pancreatic cancer cell line, MIA PaCa-2 cells, using CRISPRa for overexpression and DsiRNA for knockdown. They showed that ANGPTL4 overexpression led to in vitro resistance to gemcitabine and reduced survival times in patients.
[BMC Cancer] |
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| Researchers showed that eliminating abnormal bone marrow-derived cells using bone marrow transplantation resulted in controlling serum glucose in diabetic mice, in which normoglycemia was sustained even after cessation of insulin therapy.
[Communications Biology] |
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| Using a combination of patient and syngeneic murine models, scientists investigated the effects of the bromo- and extra-terminal domain drug BMS-986158 on cellular proliferation, organoid growth, cell cycle progression, and mitochondrial metabolic disruption.
[Molecular Cancer Therapeutics] |
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| SiRNA and plasmids were applied to investigate the effects of PRKRA on pancreatic cancer cells. Organoids and cell lines with knockout and overexpression of PRKRA were established by CRISPR/Cas9 and lentivirus.
[Heliyon] |
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| The authors provide an up-to-date overview of drugs targeting KRAS and other molecular targets in pancreatic cancer.
[Current Treatment Options In Oncology] |
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| | The company will conduct a Phase I multi-regional, open-label, clinical trial in patients with advanced refractory solid tumors with HER2 low and HER2+ expression. HER2-expressing solid tumors include breast, bladder, pancreatic, ovarian, stomach, colon, prostate, lung, uterus, and cervix cancers.
[HighField Biopharmaceuticals] |
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| June 28 – July 1, 2023
Alpbach, Austria |
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| | City of Hope – Duarte, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | City of Hope – Duarte, California, United States |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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