 | | Vol. 14.24 – 27 June, 2023 |
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| The authors developed a novel and specific nanodelivery platform for type 1 diabetes that targeted high endothelial venules presented in the pancreatic lymph nodes and pancreas.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Mutation of the endogenous NKX2.2- specific domain prevented the developmental progression of β cell precursors into mature, insulin-expressing β cells, resulting in overt neonatal diabetes.
[Genes & Development] |
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| Pancreatic beta cell-specific Cpe knockout mice (βCpeKO) lacked mature insulin granules and had elevated proinsulin in plasma; however, glucose-and KCl-stimulated insulin secretion in βCpeKO islets remained intact.
[Diabetes] |
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| Researchers designed a combinatorial variant antibody library to optimize the activity of TB-001-003 against glucagon-like peptide 1 receptor (GLP-1R), and performed phage-display on cells overexpressing GLP-1R.
[Diabetes] |
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| Scientists examined the potency of both palmitoleic acid (POA) isomers to potentiate insulin secretion in murine and human pancreatic β cell lines, and whether POA isomers activated G protein-coupled receptors proposed as potential targets for type 2 diabetes mellitus treatment.
[Food & Function] |
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| In a caerulein-induced mouse model of acute pancreatitis, treatment with Acetyl-11-keto-β-boswellic acid (AKBA) reduced blood amylase and lipase activity and ameliorated pancreatic tissue histological and pathological features.
[International Immunopharmacology] |
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| | The combination of irreversible electroporation and a custom micelle nanoformulation significantly prolonged animal survival in both subcutaneous and orthotopic murine PDAC models, and elicited CD8+ T cell-mediated antitumor immunity with a sustained antitumor memory.
[ACS Nano] |
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| Investigators identified NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites were enriched in NR5A2 ChIP-Sequencing peaks.
[Nature Communications] |
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| Circular RNA ARFGEF2 (CircARFGEF2) overexpression significantly facilitated KRASG12D PDAC lymph node metastasis in vitro and in vivo.
[Cancer Research] |
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| The function of nucleolar and spindle associated protein 1 (NUSAP1) in PDAC progression was clarified by single-cell RNA-seq and further experiments in vitro, xenograft mouse model, spontaneous PDAC mice model, and human tissue microarray.
[Cancer Letters] |
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| The authors summarize experiences since the discovery of glucagon regarding basic and clinical aspects of this hormone and speculations on the future directions for glucagon biology and glucagon-based therapies.
[Diabetologia] |
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| A combination strategy of endoscopic ultrasound-guided radiofrequency ablation with chemotherapy for pancreatic cancer will be studied at UTHealth Houston through a $3.3 million grant from the National Cancer Institute by the US Department of Health and Human Services.
[McGovern Medical School] |
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| September 27 – 29, 2023
Boston, Massachusetts, United States |
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| | Joslin Diabetes Center – Boston, Massachusetts, United States |
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| | University of Southern Denmark – Odense, Denmark |
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| | Springer Nature Ltd – New York City, New York, United States |
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| | City of Hope – Duarte, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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