 | | Vol. 14.25 – 4 July, 2023 |
| |
|
|
| Upon a viral insult, ARGI was upregulated in the nuclei of pancreatic β cells and bound to CTCF to interact with the promoter and enhancer regions of IFNβ and interferon-stimulated genes.
[Advanced Science] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Researchers generated and analyzed mice in which the Nkx2.2 SD was mutated and found that the SD was required for normal pancreatic islet differentiation, but dispensable for most aspects of neuronal differentiation.
[Genes & Development] |
|
|
|
| The authors demonstrated that arginine 65 methylation of Neurogenin 3 was a key molecular switch in human embryonic stem cells permitting their differentiation into pancreatic endocrine cells.
[Experimental & Molecular Medicine] |
|
|
|
| Metabolomics analysis revealed that calcium/calmodulin dependent protein kinase IV (CAMK4) overexpression caused alterations of amino acid, lipid, and carbohydrate metabolism, which were important in gestational diabetes mellitus.
[Molecular Medicine] |
|
|
|
| To test the hypothesis that enzyme short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD)-congenital hyperinsulinism of infancy arises from a specific defect in pancreatic β-cells, investigators created genetically engineered β-cell-specific or hepatocyte-specific SCHAD knockout mice.
[Journal Of Biological Chemistry] |
| |
|
|
| Dual-specificity phosphatase 2 (DUSP2) significantly promoted apoptosis in PDAC both in vitro and in vivo, mainly through AKT1 rather than ERK1/2.
[Cancer Letters] |
|
|
|
| To characterize the epigenetic landscape of genetically engineered mouse models of PDAC, with or without KRAS and/or TP53 mutations, scientists employed ATAC-seq, H3K27ac ChIP-seq, and RNA-seq.
[British Journal Of Cancer] |
|
|
|
| Silence of NSUN2 by lentivirus weakened the capability of proliferation, migration and invasion of pancreatic cancer cells in vitro, and inhibited the growth and metastasis of xenograft tumors in vivo.
[Cell Death Discovery] |
|
|
|
| After calculating 502 telomere-associated differentially expressed genes, researchers constructed a three-gene prognostic signature that could be effectively applied to the prognostic classification of pancreatic cancer patients in multiple datasets.
[Scientific Reports] |
|  |
|
|
|
| The authors summarize current challenges for promoting longevity of grafts, and discuss possible strategies for improving islet graft longevity.
[Acta Biomaterialia] |
|
|
|
|
| Fred Hutchinson Cancer Center pancreatic cancer researcher Sita Kugel, PhD, has received an inaugural Translational Research Award from the V Foundation for Cancer Research.
[Hutch News] |
|
|
|
|
| August 6 – 11, 2023
Newry, Maine, United States |
|
|
|
|
|
| | University of Southern Denmark – Odense, Denmark |
|
|
|
| | The National University of Singapore – Singapore, Singapore |
|
|
|
| | Springer Nature Ltd – New York City, New York, United States |
|
|
|
| | City of Hope – Duarte, California, United States |
|
|
|
| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
