 | | Vol. 14.26 – 11 July, 2023 |
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| Using high-throughput screening assays, the authors identified telaprevir as a potent pancreatic elastase inhibitor that could increase human and rodent β cell viability in vitro and in vivo, and improve glucose tolerance in insulin-resistant mice.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| It was shown that mesenchymal stem cells (MSCs) delivered hypoxia-treated functional mitochondria to damaged pancreatic acinar cells (PACs) via extracellular vesicles, which reversed the metabolic function of PACs, maintained ATP supply, and exhibited an excellent injury-inhibiting effect.
[Advanced Science] |
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| Mouse islets exposed to BMP-2 for 10 days showed impaired glucose-stimulated insulin secretion and beta cell proliferation, and BMP-2-induced beta cell dysfunction was associated with decreased expression of cell maturity and proliferation markers specific to the beta cell.
[Cell Death & Disease] |
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| Researchers used mice with heterozygous deletion of raptor in β-cells to assess whether reduced mTORC1 function was critical for β-cell function in normal conditions, or during β-cell adaptation to high-fat diet.
[Molecular Metabolism] |
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| Stromal cell-derived factor 1 (SDF-1) protected islet cells from cytokine-induced apoptosis in vitro. Suppressor of cytokine signaling 3 (SOCS3)-knockout islets pretreated with SDF-1 were effective in reducing blood glucose in non-obese diabetic mice in vivo.
[Current Stem Cell Research & Therapy] |
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| The authors proposed a biomimetic “Nutri-hijacker” with “Trojan horse” design to induce synthetic lethality in KRAS-mutated malignant cells by hitchhiking and reprogramming the metabolic addictions.
[ACS Nano] |
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| When expressed in cells as genetically encoded reagents, these monobodies engaged selectively with KRAS(G12D) and inhibited KRAS(G12D)-mediated signaling and tumorigenesis.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Inhibition of phosphodiesterase 4D and the elevation of cAMP levels blocked mTORC1 signaling via Raptor phosphorylation. Pancreatic cancer exhibited an upregulation of phosphodiesterase 4D expression, and high levels predicted the poor overall survival of patients with pancreatic cancer.
[JCI Insight] |
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| Using random forest classifier, probabilities of three patterns could be predicted on pancreatic cancer cell lines, which could be used to find vulnerable targets in response to both genetic and drug perturbation.
[Cancer Gene Therapy] |
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| The authors summarize the biology, current treatments, and molecular profiles of gastro-entero-pancreatic neuroendocrine carcinoma based on the findings of pivotal comprehensive molecular analyses.
[Cancer And Metastasis Reviews] |
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| Scientists abridge the crosstalk between the inflammation and highlight the dysregulation in physiological consequences due to diabetes mellitus, and review various treatments available for its related physiological complications.
[International Immunopharmacology] |
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| The US FDA approved Lantidra, the first allogeneic pancreatic islet cellular therapy made from deceased donor pancreatic cells for the treatment of type 1 diabetes.
[FDA] |
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| August 3, 2023
New York, New York, United States |
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| | Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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| | University of Southern Denmark – Odense, Denmark |
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| | The National University of Singapore – Singapore, Singapore |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | City of Hope – Duarte, California, United States |
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