 | | Vol. 14.27 – 18 July, 2023 |
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| Patient-derived xenografts were generated from 25 patients with germline BRCA PDAC at different clinical time points. Response to platinum/PARP inhibition in vivo and ex vivo culture correlated with clinical response.
[Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Phosphatidylinositol transfer protein alpha (PITPNA) in beta-cells of type 2 diabetes human subjects was markedly reduced suggesting its depletion accompanied beta-cell dysfunction.
[Nature Communications] |
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| Receptor and channel binding assays were conducted to evaluate the drug safety of a dextromethorphan derivative. Pancreatic islets were used to investigate the effect of the compound on insulin secretion and islet cell survival.
[Molecular Metabolism] |
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| EndoC-βH5 cells were generated by integrative gene transfer of immortalizing transgenes hTERT and SV40 large T along with Herpes Simplex Virus-1 thymidine kinase into human fetal pancreas.
[Molecular Metabolism] |
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| Scientists investigated the role of MYD88/IRAK using Irak3−/− mice in two experimental animal models of mild and severe acute pancreatitis. IRAK3 was expressed in macrophages as well as pancreatic acinar cells, where it restrained NFκB activation.
[Scientific Reports] |
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| Mechanistically, as an RNA binding protein, BICC1 bound to the 3’UTR of Lipocalin-2 mRNA and post-transcriptionally up-regulated LCN2 expression in pancreatic adenocarcinoma cells.
[Signal Transduction And Targeted Therapy] |
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| Scientists showed that mesenchymal-like KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte–mediated killing than the parental epithelial–like cells.
[Science Advances] |
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| Investigators reported that cRGD peptide-modified bioresponsive chimaeric polymersomes mediated highly efficient siKRAS delivery to PANC-1 tumor, potently silencing KRAS G12D mRNA in tumor cells and effectively suppressing pancreatic cancer tumor growth in mice.
[Acta Biomaterialia] |
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| Researchers identified YWHAZ as a key regulator of pancreatic cancer metastasis, and demonstrated that functional activation of Ywhaz by the gene search vector led to enhanced metastatic capability in mouse pancreatic cancer cells.
[Cell Death & Disease] |
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| The authors review the molecular mechanisms, and other factors related to the metastasis of pancreatic cancer, and discuss the consequences and negative effects associated with metastasis itself.
[Cancer And Metastasis Reviews] |
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| Scientists review studies addressing the accumulation and activity of intrapancreatic adipocytes in the pancreas (IPAs), revealing that an unexpectedly diverse group of factors cause replacement of acinar tissue with IPAs, particularly in the mouse models that are essential tools for research into pancreatic cancer.
[Cellular And Molecular Life Sciences] |
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| ImPact Biotech announced the FDA granted Orphan Drug Designation to Padeliporfin Vascular Targeted Photodynamic therapy (VTP) for the treatment of patients with locally advanced pancreatic cancer.
[ImPact Biotech (GlobalNewswire)] |
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| September 13 – 15, 2023
Seogwipo, South Korea |
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| | Aarhus University – Aarhus, Denmark |
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| | Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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| | University of Southern Denmark – Odense, Denmark |
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| | The National University of Singapore – Singapore, Singapore |
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| | City of Hope – Duarte, California, United States |
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Cancer Stem Cell News
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