 | | Vol. 14.28 – 25 July, 2023 |
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| Targeting both tumor-derived exosomes and the primary tumor is challenging. Based on metabolic glycoengineering and bio-orthogonal click chemistry, a two-step delivery strategy was designed to overcome this.
[Advanced Materials] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To study the role of mTORC1 in mediating hyperglucagonaemia in diabetes, researchers generated an inducible alpha cell-specific Rptor knockout in the Akita mouse model of diabetes, and tested the effects on glucose tolerance by IPGTT and on glucagon secretion.
[Diabetologia] |
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| Mice with elevated 3-hydroxykynurenine succumbed fatally earlier and more readily to experimental acute pancreatitis. Therapeutically, blockade with the highly selective kynurenine monooxygenase inhibitor GSK898 rescued the phenotype, reducing 3-hydroxykynurenine and protecting against critical illness and death.
[Cell Reports] |
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| Mechanistic assays demonstrated that the sexually dimorphic phenotype observed in mice with a β cell-specific stromal interaction molecule 1 deletion was due, in part, to loss of signaling through the noncanonical 17-β estradiol receptor.
[Diabetes] |
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| Overexpression of the ubiquitin-binding enzyme 2C (UBE2C) via lentiviral transduction in pancreatic islets was able to relaunch β-cell proliferation in STZ-induced diabetic mice, and therefore partially alleviated hyperglycaemia and glucose intolerance.
[Cellular And Molecular Life Sciences] |
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| Investigators aimed to elucidate the in situ expression pattern of angiotensin I-converting enzyme type 2 in Type 2 diabetes with respect to non-diabetic donors, which may account for a higher susceptibility to SARS-CoV-2 infection in beta-cells.
[Diabetes-Metabolism Research And Reviews] |
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| The authors demonstrated potent efficacy of pan-RAF and MEK inhibition in patient-derived organoid models carrying BRAF in-frame deletions.
[Clinical Cancer Research] |
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| Knockout of B3GNT3 or deletion of enzymatically active B3GNT3 sensitized PDAC cells to ferroptosis. Reconstitution of 4F2hc-deficient cells with wildtype 4F2hc restored ferroptosis resistance, while glycosylation-mutated 4F2hc did not.
[Cell Death & Differentiation] |
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| Experiments revealed that ZFAS1-rich exosomes released from cells suffering glucose and glutamine deprivation promoted the epithelial–mesenchymal transition and metastasis of recipient pancreatic cancer cells.
[Cancer Science] |
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| New findings suggest that a collective of cellular constituents—immune, endocrine, and exocrine in origin—mechanistically coalesce to facilitate type 1 diabetes. Scientists consider these emerging concepts, from basic science to clinical research, and identify several key remaining knowledge voids.
[Cell Metabolism] |
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| The authors disucss the heritability of the disease, the development of genetic risk scores, differences in trans-ancestry and ancestry-specific scores, and more.
[Diabetologia] |
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| Scientists discuss the current diagnostic approaches and clinical applications of genetic analysis in pancreatic cancer and diagnostic attempts by liquid biopsy and molecular analyses using pancreatic juice, duodenal fluid, and blood samples.
[Journal Of Gastroenterology] |
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| The spike in childhood type 1 diabetes opened new avenues for researchers to explore the cause of the disease.
[Nature News] |
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| September 20 – 23, 2023
Milan, Italy |
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| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| | Aarhus University – Aarhus, Denmark |
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| | Rutgers Cancer Institute of New Jersey – New Brunswick, New Jersey, United States |
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| | University of Southern Denmark – Odense, Denmark |
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| | Springer Nature Ltd – New York City, New York, United States |
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