Pancreatic Cell News Volume 14.31 | Aug 8 2023

    By
    Jamie Kang
    -
    0
    50







    2023-08-08 | PACN 14.30


    Pancreatic Cell News by STEMCELL Technologies
    Vol. 14.30 – 8 August, 2023
    TOP STORY

    Tryptophan Metabolism Promotes Immune Evasion in Human Pancreatic β Cells

    Key results were validated by monitoring the activity of CD8+ Jurkat T cells presenting β cell-specific T cell receptor and transduced with reporter genes in contact culture with the human β cell line, ECN90.
    [Ebiomedicine]

    Full Article
    See how small molecules affect key signaling pathways in cancer research. Download your free wallchart now.
    PUBLICATIONSRanked by the impact factor of the journal

    SERCA2 Regulates Proinsulin Processing and Processing Enzyme Maturation in Pancreatic Beta Cells

    Researchers generated mice with beta cell-specific sarcoendoplasmic reticulum Ca2+ ATPase-2 (SERCA2) deletion and used an INS-1 cell line model of SERCA2 deficiency.
    [Diabetologia]

    Full Article

    Pericyte Dysfunction and Impaired Vasomotion Are Hallmarks of Islets during the Pathogenesis of Type 1 Diabetes

    The authors investigated islet pericyte density, phenotype, and function using living pancreas slices from donors without diabetes, donors with a single type 1 diabetes (T1D)-associated autoantibody, and recent onset T1D cases.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The SSBP3 Co-Regulator Is Required for Glucose Homeostasis, Pancreatic Islet Architecture, and Beta-Cell Identity

    Investigators developed a novel SSBP3 LoxP allele mouse line, where Cre-mediated recombination imparted a predicted early protein termination.
    [Molecular Metabolism]

    Abstract

    CRIP1 Fosters MDSC Trafficking and Resets Tumour Microenvironment via Facilitating NF-κB/p65 Nuclear Translocation in Pancreatic Ductal Adenocarcinoma

    Researchers investigated the mechanism of tumor cells in tumor immune microenvironment formation and provided potential combination treatment strategies for PDAC patients based on genotypic heterogeneity.
    [Gut]

    Abstract

    Treatment Response in First-Line Metastatic Pancreatic Ductal Adenocarcinoma Is Stratified By a Composite Index of Tumor Proliferation and CD8 T-Cell Infiltration

    Patients with treatment-naïve metastatic PDAC were enrolled in a Phase II trial investigating gemcitabine plus nab-paclitaxel in combination with indoximod, an orally administered small-molecule inhibitor of the IDO pathway.
    [Clinical Cancer Research]

    Abstract

    Enhancing Chemotherapy for Pancreatic Cancer through Efficient and Sustained Tumor Microenvironment Remodeling with a Fibroblast-Targeted Nanosystem

    Scientists developed a novel cancer-associated fibroblasts-tailored nanosystem loaded with a potent anti-fibrosis flavonoid compound, which possessed biological responsiveness to fibroblast activation protein alpha, prolonged tumor microenvironment remodeling, and enhancement of clinical chemotherapeutics.
    [Journal Of Controlled Release]

    AbstractGraphical Abstract

    Black Phosphorus as a Targeting PPAR-γ Agonist to Reverse Chemoresistance in Patient-Derived Organoids, Mice, and Pancreatic Tumor Cells

    Black phosphorus-activated PPAR-γ inhibited cancer stem cell properties and expression of biomarkers such as CD44 and c-Myc, which are involved in chemoresistance. Notably, CD44 overexpression in tumor cells rendered them susceptible to black phosphorous, while insensitive to gemcitabine.
    [Advanced Healthcare Materials]

    Abstract

    Momordicae Semen Inhibits Migration and Induces Apoptotic Cell Death by Regulating C-Myc and CNOT2 in Human Pancreatic Cancer Cells

    Researchers investigated whether the Momordicae Semen extract exerted an anti-cancer effect by regulating c-Myc through CNOT2. Cytotoxicity and proliferation were investigated using MTT and colony formation assays.
    [Scientific Reports]

    Full Article
    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff ™ and TeSR ™-AOF, presented by Kim Snyder. Click to Watch Now.
    REVIEWS

    The Role of Epithelial-Mesenchymal Transition and Autophagy in Pancreatic Ductal Adenocarcinoma Invasion

    The authors discuss the characteristics and the biological role of epithelial-mesenchymal transition (EMT) and autophagy from a cellular perspective, explaining invasion as a survival behavior of PDAC, with the aim of providing novel insights into targeting EMT and autophagy to overcome PDAC invasion.
    [Cell Death & Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    Theriva™ Biologics Announces Key Progress in VIRAGE, an Ongoing, Multinational Phase IIb Trial of VCN-01 in Combination with Chemotherapy in Pancreatic Ductal Adenocarcinoma

    Theriva™ Biologics announced key progress in VIRAGE, a multinational, Phase IIb, randomized, open-label, controlled clinical trial evaluating VCN-01 in combination with standard-of-care chemotherapy as a first-line therapy for patients with metastatic PDAC.
    [Theriva™ Biologics (Globe Newswire)]

    Press Release
    FEATURED EVENT

    Trafficking Pathways in Neurodegeneration

    September 6 – 8, 2023
    Hinxton, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Pancreatic Cancer Research

    National Institute of Health – Bethesda, Maryland, United States

    Assistant/Associate Professor – Immunology of Pancreatic Disorders

    Stanford University – Stanford, California, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Researcher – Pancreas Organoid Mechanics and Hydraulics

    Max Planck Institute – Dresden, Germany

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Pancreatic Cell News Twitter